The Systemic Lupus Erythematosus (SLE
) pipeline is characterized by a high level of first-in-class innovation when compared to other therapy areas and the industry as a whole.
A recent nationwide study using causes of death from 1968 through 2013 obtained from death certificate data in CDC's WONDER database (https:// wonder.cdc.gov) showed that age-standardized mortality rates decreased over time among SLE
patients but remained high relative to non-SLE mortality, with the highest mortality rates in women, blacks, and residents of the South and West U.S.
The predictors found to have association with pulmonary arterial hypertension in SLE
patients were raynaud's phenomenon, urinary proteins and rheumatoid factor, with a significant p-value (<0.05) Table-II.
The demographic and clinical characteristics, including gender, age, and SLE
duration, did not differ between the SLE
patients with and without infection.
Analysis of Cytokines Production by SLE
Patients and Healthy Controls.
Gene Expression and Immune Variables in ILE and SLE
. Expression of the Type I IFN gene signature that is elevated in SLE
was probed by measuring expression levels of three specificities, MX1, OAS1, and IFI27.
The discovery of lupus erythematosus cellby Hargraves in 1940sinitiated many studies of SLE
around the globe.1SLE is a chronic multisystemdisease due to deposition of antigen-antibody complexes in various tissuescausing a wide variety of organ specific symptomatology.2-4This disorder usually is chronic with relapsing remitting nature and a threat for fatal outcomes.3Skin-related manifestations of SLE
gives important information about diagnosis and disease activity.
* What are the remaining opportunities in the SLE
and LN markets?
is more common in people of African Carib-bean and Asian origin than in white population (Rah-man et al 2008).
Exclusion criteria included illiteracy, cognitive incompetence, a history of schizophrenia or related psychotic disorders, a history of neurologic diseases or severe neurologic manifestations of SLE
, concomitant serious medical illnesses such as uncontrolled endocrine abnormalities, cardiovascular disease, movement disorder, and the use of psychotropic medication within the last 4 weeks.
The sharp rise in total knee replacement (TKR) among systemic lupus erythematosus (SLE
) patients has been driven by a hefty increase in operations performed for osteoarthritis, while TKR for active SLE
in the knee has declined.
is a systemic autoimmune disorder characterized by presence of autoantibodies against self-nuclear components that resulted in chronic inflammation of various tissues and organs .