Paroxysmal exercise-induced dyskinesia and epilepsy is due to mutations in SLC2A1
, encoding the glucose transporter GLUT1.
FGF21 increases glucose transport into adipose cells by inducing solute carrier family 2 (facilitated glucose transporter), member 1 (SLC2A1
), the glucose transporter 1 (GLUT1) facilitative glucose transporter.
The only one study available in the literature has demonstrated that AA BM-MSC have a normal phenotype and can be readily differentiated into adipocytes with increased expression of genes of adipocytokine signaling pathway including TRADD, PRKAB2, LEP, SLC2A1
, and sOcS3 .
RT-PCR was performed using Roche FastStart DNA Master HybProbe (Roche) and Taqman primers and probes for fatty acid synthase (FASN; Hs01005622), glycerol-3-phosphate acyltransferase (GPAM; Hs0157368), solute carrier family 2, member 1 (GLUT1, also known as SLC2A1
; Hs0089268), Solute Carrier Family 2, member 4 (GLUT4, also known as SLC2A4; Hs00168966), Solute Carrier Family 2, member 5 (GLUT5, also known as SLC2A5; Hs0016172), adiponectin (Hs00605917), leptin (Hs00174877), and interleukin 6 (IL6; Hs00985639) obtained from Life Technologies.
(31) HIF-1[alpha] is a transcription factor that regulates expression of numerous downstream target genes including vascular endothelial growth factor (VEGF), platelet-derived growth factor [beta] (PDGFB), transforming growth factor [alpha] (TGFA), glucose transporter 1 SLC2A1
(GLUT1), and carbonic anhydrase IX (CA9), all of which are important in angiogenesis and for maintaining cellular homeostasis under hypoxic conditions.