Beta-lactam group of antimicrobials are frequently associated with severe cutaneous adverse drug reaction CADRs like SJS
From a total of 97 patients with such skin disorders, we identified SJS
in 89 (91.8 %), TEN in 5 (5.1%), and SJS/TEN overlap in 3 (3.1%) patients.
Combination treatment was more commonly used in TEN patients than in SJS
patients (64.9% versus 20.8%) (Odds ratio: 7.024; P < 0.001) (Table 1).
The aim of this study was to determine the causes and treatment outcome of SJS
and TEN cases admitted to Miri General Hospital between year 2011 and 2015.
Mortality was 0% for SJS
, 4% for SJS/TEN, and 16% for TEN.
and TEN are considered T cell mediated disorders in which activation of CD8 T lymphocytes results in apoptosis and necrosis of keratinocytes6.
Type IA: The most commonly recognized and described form of SJS
is type IA, which exhibits muscle stiffness, mild and largely nonprogressive muscle weakness, and a number of minor morphologic abnormalities.
The number of colored spots was 3.9 [+ or -] 0.2 in the SjS
group, 4.0 [+ or -] 0.1 in the SSc group, and 3.6 [+ or -] 0.4 in the non-SjS/non-SSc group, with significant differences among the three groups (P < 0.001).
is named after two American pediatricians Albert Mason Stevens and Frank Chambliss Johnson who jointly published the first description of the disorder in the American Journal of Diseases of Children in 1922.2 Stevens-Johnson Syndrome (SJS
) is an immune-complex-mediated hypersensitivity reaction that characteristically involves skin and mucous membrane.
Numerous drugs can cause SJS
, with several antituberculosis drugs,'111 aromatic anticonvulsants (e.g.
The panel agreed the drug was effective but was mainly concerned about its potential to cause Stevens-Johnson syndrome (SJS
) in this population.
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