and S100A9 in cardiovascular biology and disease.
Expression Is Associated With Poor Prognosis and Verified Using Imaging Mass Spectral Assessment of Patient Tissues
Studies have shown that S100A8
plays an important role in tumorigenesis and inflammation.
In models of acute hepatitis mediated by Con A and a-GalCer, farnesoid X receptor (FXR) activation drives the accumulation of MDSCs to liver via upregulation of S100A8
and augments the suppressive function of MDSCs through upregulation of receptor paired immunoglobulin-like receptor B (PIR-B) by binding the PIR-B promoter .
In addition, we analyzed HMOX1 [heme oxygenase (decycling) 1], which encodes a molecule with cytoprotective facilities, and S100A8
(S100 calcium binding protein A8), which encodes a granulocyte-derived molecule associated with chronic and acute inflammation.
Morozova-Roche, "Pro-inflammatory S100A8
and S100A9 proteins: Self-assembly into multifunctional native and amyloid complexes," International Journal of Molecular Sciences, vol.
Of these proteins, S100A8
(also known as myeloid-related protein 8 and calgranulin A), S100A9 (myeloid-related protein 14, calgranulin B), and S100A12 (calgranulin C) have prompted particular interest among rheumatologists because they are valuable markers of phagocyte activation (2).
III]-exposed cells; and in quadrant IV S100A8
For qPCR data, we normalized all transcript abundances to the 3 genes in the saliva internal reference (SIR): ANXA2 (annexin A2),  RPL37 (ribosomal protein L37), and S100A8
(S100 calcium binding protein A8) (see Supplementary Methods in the online Data Supplement).
Chemiluminescence (SuperSignal Chemiluminescent Substrate, Pierce), autoradiography, and densitometry (GS-800 Densitometer, Bio-Rad) were used to determine relative quantities of the immunoreactive bands matching the migration of S100A8
Differential detection of S100A8
in transitional cell carcinoma of the bladder by pair wise tissue proteomic and immunohistochemical analysis.
and S100A9 were purchased from Bachem AG.