Expression of S100 proteins in normal human tissues and common cancers using tissue microarrays: S100A6, S100A8
, S100A9 and S100A11 are all overexpressed in common cancers.
In this study, we show that in AML cells S100A8
and S100A9 expression is downregulated by JQ1 and upregulated by the anthracycline daunorubicin.
Zhang et al., "Methylation of S100A8
is a promising diagnosis and prognostic marker in hepatocellular carcinoma," Oncotarget, vol.
When neutrophils adhere to fibronectin in the presence of E2, they release the same proteins as the control cells (LF, albumin, NGAL, S100A8
, and S100A9) and, in addition, metalloproteinase 9 (MMP-9) (Figure 3(a), Table 2).
Genes involved in inflammatory regulation include annexin (ANXA1)  and S100 calcium binding protein (S100A8
, S100A9, and S100P).
Active involvement of alarmins S100A8
and S100A9 in the regulation of synovial activation and joint destruction during mouse and human osteoarthritis.
The production of S100A8
is elevated in cytotrophoblasts, placental-tissue macrophages, fibroblast-like cells, endothelial cells, and monocytic lineages.
It has been reported that the serum concentrations of S100A8
, S100A9, and IL-18 are increased in sJIA patients (3-5), but no study has been conducted to determine whether these biomarkers can be used in the diagnosis of sJIA.
Tessier et al., "Localization of S100A8
and S100A9 expressing neutrophils to spinal cord during peripheral tissue inflammation," Pain, vol.
Interestingly, a study that set out to quantify the ability of the CytoSorb polymer to adsorb abroad selection of inflammatory pathogen-associated molecular pattern molecules (PAMPs), damage-associated molecular pattern molecules (DAMPs), and cytokines from whole blood in a single compartment in vitro recirculation system provided that substantial quantities of a broad spectrum of DAMPS, PAMPS, and cytokines (i.e., S100A8
, complement C5a, procalcitonin, HMGB-1, MIP1-[alpha], IL-6, IFN-[gamma], TNF-[alpha], Staph enterotoxin TSST-1, and aflatoxin B1) were removed .
The extracellular role of other members of S100 super-family such as S100A8
and S100A9 has been studied in peripheral acute/chronic inflammatory disorders.
van den Bosch et al., "Alarmins S100A8
and S100A9 elicit a catabolic effect in human osteoarthritic chondrocytes that is dependent on toll-like receptor 4," Arthritis & Rheumatism, vol.