NIF

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NIF

Note Issuance Facility

An agreement by a syndicate of banks to buy short- and/or medium-term notes from an issuer in the event that it is unable to sell the notes on eurocurrency markets. This effectively provides credit for the issuer because, even if the issuer cannot place an issue, it will still be able to raise the funds it seeks. A note issuance facility thereby reduces the risk to an issuer of short- and medium-term debt securities.
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S100A8 and S100A9 in cardiovascular biology and disease.
Low S100A8 Expression Is Associated With Poor Prognosis and Verified Using Imaging Mass Spectral Assessment of Patient Tissues
In models of acute hepatitis mediated by Con A and a-GalCer, farnesoid X receptor (FXR) activation drives the accumulation of MDSCs to liver via upregulation of S100A8 and augments the suppressive function of MDSCs through upregulation of receptor paired immunoglobulin-like receptor B (PIR-B) by binding the PIR-B promoter [132].
In addition, we analyzed HMOX1 [heme oxygenase (decycling) 1], which encodes a molecule with cytoprotective facilities, and S100A8 (S100 calcium binding protein A8), which encodes a granulocyte-derived molecule associated with chronic and acute inflammation.
Morozova-Roche, "Pro-inflammatory S100A8 and S100A9 proteins: Self-assembly into multifunctional native and amyloid complexes," International Journal of Molecular Sciences, vol.
Of these proteins, S100A8 (also known as myeloid-related protein 8 and calgranulin A), S100A9 (myeloid-related protein 14, calgranulin B), and S100A12 (calgranulin C) have prompted particular interest among rheumatologists because they are valuable markers of phagocyte activation (2).
For qPCR data, we normalized all transcript abundances to the 3 genes in the saliva internal reference (SIR): ANXA2 (annexin A2), [10] RPL37 (ribosomal protein L37), and S100A8 (S100 calcium binding protein A8) (see Supplementary Methods in the online Data Supplement).
Chemiluminescence (SuperSignal Chemiluminescent Substrate, Pierce), autoradiography, and densitometry (GS-800 Densitometer, Bio-Rad) were used to determine relative quantities of the immunoreactive bands matching the migration of S100A8 monomers.
Differential detection of S100A8 in transitional cell carcinoma of the bladder by pair wise tissue proteomic and immunohistochemical analysis.
Human S100A8 and S100A9 were purchased from Bachem AG.