Evaluation of
respiratory chain activity in lymphocytes of patients with Alzheimer disease," Metabolic Brain Disease, vol.
One aspect of mitochondria is the generation of reactive oxygen species, or ROS, the main source in the body from oxygen utilization by
respiratory chain reactions.
Her team continues to work to explore the many different consequences of mitochondrial
respiratory chain dysfunction in animal models, and ways in which these consequences might themselves be treated.
59) Glycolsis, citric acid cycle and [beta]-oxidation biochemical pathways produce a high potential energy yielding reducing substance (NADH) that enters
respiratory chain (RC).
The reduced
respiratory chain component, in turn, passes the electron on to other molecules in the
respiratory chain until it is finally transferred to [O.
Deficiencies in complex I subunits of the
respiratory chain in Parkinson's disease.
Determination of Activities of the
Respiratory Chain Complexes.
The morphological abnormalities were accompanied by reduced activity of
respiratory chain complexes II and IV.
Coenzyme Q10 (CoQ10), [4] also called ubiquinone, is an essential part of the mitochondrial
respiratory chain that transforms energy in the diet to ATP for cellular functions (1).
For example, Tiina Karu, PhD, showed that
respiratory chain molecules (such as cytochrome c oxidase) in the mitochondria absorb visible and near-infrared radiation.
The results showed that SMND-309 decreased neurological deficit scores, reduced the number of dead hippocampal neuronal cells in accordance with its depression on mitochondria swelling degree, reactive oxygen species production, improvements on mitochondria swelling, energy metabolism, membrane potential level and mitochondrial
respiratory chain complex activities.
The brain is critically dependent on a continuous energy supply generated through oxidative phosphorylation in
respiratory chain and is vulnerable to damage by hypoxia (4, 5).
