Threshold

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Threshold

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6) However, the level of glucosuria does not typically rise in tandem because the capacity of the kidney to reabsorb glucose (ie, Tm glucose) is increased in diabetes, resulting in an increased renal threshold for glucose excretion (~200 to 250 mg/dL).
Canagliflozin (Invokana) increases glucose excretion, independent from insulin secretion by blocking the transporter (SGLT2) responsible for 90% of glucose reabsorption in the proximal tubules of the kidneys, and lowers the renal threshold for glucose.