The platform utilises a device called a punctal plug
, which is easily inserted into a patient's punctum.
insertion improves subjective and objective measures of OSD and results in a reduced IOP in patients with symptomatic ocular surface disease using prostaglandin analogue monotherapy," the authors write.
The company's proprietary punctal plug
design has demonstrated excellent lower punctum retention rates of 92% and 96% over a 12-week follow-up period in two separate multi-centre US clinical trials.
There have also been reports of secondary canaliculitis associated with the use of oral 5-fluorourasil in breast cancer treatment and more recently, due to trauma related to the insertion of punctal plugs
. (15,16,17) We found that one of our patients had secondary canaliculitis due to an eyelash entering the canaliculus.
This new patent complements earlier issued US patent claims directed to the proprietary punctal plug
for non-invasive sustained delivery of topical drugs to the eye.
The clinical efficacy of silicone punctal plug
30 August 2011 - Canadian ocular products developer QLT Inc (TSX:QLT) announced yesterday positive results of its Phase II clinical study on the efficacy and safety of the Latanoprost Punctal Plug
Delivery System (LPPDS) in subjects with ocular hypertension (OH) and open-angle glaucoma (OAG).
Tear duct plugs are also known as punctal plugs
or lacrimal plugs.
On the basis of products, the dry eye disease market is categorized into artificial tears, anti-inflammatory drugs, punctal plugs
, secretagogue and others.
Treatments considered in the second step include tea tree oil treatment for Demodex, preservative-free artificial tears (to avoid the toxic effects of preservatives), punctal plugs
, moisture chamber devices and goggles to maintain moisture and temperature, overnight ointment application, removing blockages from the meibomian glands using a warming and expression device (such as Lipiflow), intense pulsed light therapy for MGD, and topical administration of drugs such as corticosteroids, antibiotics, secretagogues, non-glucocorticoid immunomodulators (cyclosporine and tacrolimus (24)), LFA-1 antagonist drugs (lifitegrast), and oral macrolide or tetracycline antibiotics.
* Impacted punctal plugs
- Studies have documented an increased risk of canaliculitis and dacryocystitis associated with intracanalicular punctal plugs