These tumors are comprised of seminomas, which account for approximately 50% of cases and are derived from undifferentiated primordial germ cells
, and nonseminomas, which constitute approximately 40% of cases and exhibit different stages of differentiation.
Tang et al., "SOX17 is a critical specifier of human primordial germ cell
fate," Cell, vol.
Woodcock et al., "FGF, insulin, and SMAD signaling cooperate for avian primordial germ cell
self-renewal," Stem Cell Reports, vol.
The authors also provide compelling evidence that germline mutation rates are not constant throughout the lifetime of an organism, and that spontaneous mutation may be more likely to occur during the expansion of male primordial germ cell
precursors in embryogenesis than during other developmental stages or post-pubertal spermatogenesis.
(2015) SOX17 is a critical specifier of human primordial germ cell
The gene imprinting occurs in gametogenesis and after ovum and spermzygosis will transmite to zygote and also will be kept during genesis and in primordial germ cells
will be deleted before new imprint organization [5,6].
Regulation of zebrafish primordial germ cell
migration by attraction towards an intermediate target.
Growth factors sustain primordial germ cell
survival, proliferation and entering into meiosis in the absence of somatic cells.
Houk and Hinegardner (1980) comment on the presence of cells with recognizable NP characteristics in the genital primordium of the sea urchin Lytechinus pictus soon after metamorphosis and note their migration along with primordial germ cells
into the gonad.
Regulation of primordial germ cell
development in the mouse.
"It's very likely that the compounds affect the primordial germ cell
population being formed," she hypothesizes.
"We found that these cells (from the embryonic stem cells come) resemble in almost every feature an early germ cell (primordial germ cell
)," he said.