These tumors are comprised of seminomas, which account for approximately 50% of cases and are derived from undifferentiated
primordial germ cells, and nonseminomas, which constitute approximately 40% of cases and exhibit different stages of differentiation.
Tang et al., "SOX17 is a critical specifier of human
primordial germ cell fate," Cell, vol.
Woodcock et al., "FGF, insulin, and SMAD signaling cooperate for avian
primordial germ cell self-renewal," Stem Cell Reports, vol.
The authors also provide compelling evidence that germline mutation rates are not constant throughout the lifetime of an organism, and that spontaneous mutation may be more likely to occur during the expansion of male
primordial germ cell precursors in embryogenesis than during other developmental stages or post-pubertal spermatogenesis.
(2015) SOX17 is a critical specifier of human
primordial germ cell fate.
The gene imprinting occurs in gametogenesis and after ovum and spermzygosis will transmite to zygote and also will be kept during genesis and in
primordial germ cells will be deleted before new imprint organization [5,6].
Regulation of zebrafish
primordial germ cell migration by attraction towards an intermediate target.
Growth factors sustain
primordial germ cell survival, proliferation and entering into meiosis in the absence of somatic cells.
Houk and Hinegardner (1980) comment on the presence of cells with recognizable NP characteristics in the genital primordium of the sea urchin Lytechinus pictus soon after metamorphosis and note their migration along with
primordial germ cells into the gonad.
Regulation of
primordial germ cell development in the mouse.
"It's very likely that the compounds affect the
primordial germ cell population being formed," she hypothesizes.
"We found that these cells (from the embryonic stem cells come) resemble in almost every feature an early germ cell (
primordial germ cell)," he said.