The physiological mechanisms involved in the onset of post-stroke depression haven't been fully elucidated yet.
Changjuan W, Fang Zhang L, Xiaofeng M, Nan Z, Junwei H, Factors associated with post-stroke depression and fatigue: lesion location and coping styles, Neurol, 263:269-276, 2016.
Serotonin receptor 2C gene polymorphism associated with post-stroke depression in Chinese patients.
Associations of cytokine gene polymorphisms with post-stroke depression.
A Stroke QUERI project, "Implementing Evidence in the Detection and Treatment of Post-stroke Depression," is in the planning phase.
First, researchers will identify how clinicians are detecting and treating post-stroke depression.
The relationship between post-stroke depression and recovery of function after a stroke has not been well understood.
Since treating depression helps improve function, occupational therapists should screen for post-stroke depression and, in conjunction with other members of the patient's health care team, help manage depression.
Complicating the rehabilitation from stroke, studies indicate that post-stroke depression
(PSD) may affect up to one third of stroke survivors (Creutzfeldt et al.
It also has been shown to speed recovery from post-stroke depression
so that patients can participate more fully in rehabilitation programs.
In women, rates of post-stroke depression
ranged from about 6 percent to 78 percent, while in men depression rates ranged from 4.