The study shows that during aging, Paneth cells
begin to express the secreted Wnt-inhibitor Notum, which enzymatically inactivates Wnt-ligands in the stem cell niche, decreasing regenerative potential of intestinal stem cells.
Intestinal glands in the lamina propria belong to simple tubular gland; its basement is primarily composed of columnar cells and a few goblet cells, but Paneth cells
are not observed in the crypts (Fig.
Other epithelial cells such as enteroendocrine cells and Paneth cells
were also observed.
Niederreiter et al., "Paneth cells
as a site of origin for intestinal inflammation," Nature, vol.
Ayabe, "Paneth cell
a-defensins and enteric microbiota in health and disease," Bioscience of Microbiota, Food and Health, vol.
Caption: Figure 1: Interplay of gut microbiome-intestinal epithelial cells (enterocytes, goblet cells and paneth cells
) and host metabolism and immunity.
Alcohol also affects mucosal immunity by suppressing one of the intestine's main lines of defense against bacteria, Paneth cells
that secrete antibacterial compounds.
Glands of the small intestines contain paneth cells
, enteroendocrine cells, M cells, and stem cells in addition to enterocytes and goblet cells
Host-innate immunity in the gut is influenced by paneth cells
and intestinal DCs which may be responsible for enhancing T cell immunity induced by checkpoint blockade [95, 96].
Gordon, "Developmental regulation of intestinal angiogenesis by indigenous microbes via Paneth cells
," Proceedings of the National Academy of Sciences, vol.
Histopathological evaluation of the gastrointestinal tract revealed loss of parietal cells, mild glandular disarray, acute inflammation, and apoptotic activity in the stomach (Figure 3, hematoxylin and eosin, original magnification 200x) and patchy villous atrophy and absence of goblet cells and Paneth cells
in the duodenum with crypt abscesses and apoptosis (Figure 3, hematoxylin and eosin, original magnification 200x); and in the terminal ileum, as in the duodenum, there was also an absence of goblet and Paneth cells
, with crypt dropout (Figure 3, hematoxylin and eosin, original magnification 200x).
The intestinal crypt in which IESCs reside harbors some IESCs-derived cell populations, including transit-amplifying progenitor cells, enteroendocrine cells (EECs), and Paneth cells