cGMP was significantly increased in the control group after nucleus pulposus
implantation on day 7 (P < 0.01).
Sanchez-Guijo et al., "Isolation and characterization of mesenchymal stromal cells from human degenerated nucleus pulposus
: comparison with bone marrow mesenchymal stromal cells from the same subjects," Spine, vol.
The Pfirrmann grading system, closely related to signal strengths of nucleus pulposus
and annulus fibrosis, is widely used in the clinical evaluation of IDD. However, it is neither accurate nor particularly applicable for diagnosing early disc degeneration, in large part due to subjectivity of the examiner, weak classification effects on aged intervertebral discs, and insufficient capability for accurately assessing the degree of degeneration.
Thomas et al., "Functional compressive mechanics of a PVA/PVP nucleus pulposus
replacement," Biomaterials, vol.
Rydevik, "Ultrastructural changes in spinal nerve roots induced by autologous nucleus pulposus
," Spine, vol.
Our present data concurs with previous discoveries, in which [H.sub.2][O.sub.2] could also aggravate the apoptosis incidence of nucleus pulposus
cells and osteoblasts [38, 41].
Human Nucleus Pulposus
Cells Were Successfully Separated and Cultured (The Cell Photograph Was Shown in Figure 1(a)).
The nucleus pulposus
of the cervical intervertebral disc was ablated by radiofrequency (RF) ablation; the mobilization of the nerves root was repeatedly checked (Figure 2).
Condoliase is being developed for use as a chemonucleolysis treatment to break down selected components of the IVD, primarily within the nucleus pulposus
. This reduces its water content and volume, thereby relieving disc pressure and compression on the spinal nerve root, concluded the company.
The nucleus pulposus
part of the intervertebral disc is formed from the notochord cells while the annulus fibrosus develops from the mesenchymal cells.
miR21 promotes human nucleus pulposus
cell proliferation through PTEN/AKT signaling.
In 1929, Schmorl reported his observation of "nodules" associated with the disc; he believed them to be a result of a prolapsed nucleus pulposus
and associated with a degenerative or traumatized annulus fibrosus.