Type II collagen is the most widely distributed collagen in normal human intervertebral discs, which shows a progressive increase from the periphery toward the center of the nucleus pulposus
Kim, "In vitro lifespan and senescence mechanisms of human nucleus pulposus
chondrocytes," Spine Journal, vol.
This nutrition later reaches the nucleus pulposus
through diffusion in pores around the endplates.
In conclusion, our study indicates that minimally invasive procedures, such as RFTC nucleoplasty and TDD, are effective and safe methods that can be used in hernia nucleus pulposus
as an alternative to surgery.
Interestingly, if the nucleus pulposus
is sufficiently desiccated, it exerts less pressure against the annular fibers and the likelihood of a bulging or herniated disc actually goes down.
In Group C, thirteen of fifteen discs showed atrophy of Nucleus Pulposus
and myxomatous degeneration (annular collagen fiber swollen and in reversed direction).
Low back pain associated with varices of the epidural veins simulating herniation of the nucleus pulposus
It is well-known that the nucleus pulposus
contains negative charges, which generate an osmotic gradient, attracting water to the spaces between glycosaminoglycan molecules (BRAY & BURBIDGE, 1998a).
And they develop cracks or small tears in the outer layer, the annulus fibrosis, which can cause the inner layer, the nucleus pulposus
, to be forced out, resulting in a bulging, herniated, or even ruptured disc.
Researchers found that cells extracted from the nucleus pulposus
(the jelly-like tissue in the center of the spinal discs) and exposed, in vitro, to lovastatin (Altoprev, Mevacor) demonstrated increased synthesis of collagen II, a protein that makes up moveable joints.
The ID is composed of a gelatinous structure called nucleus pulposus
surrounded by a fibrous-resistant structure called annulus fibrosus.
A Finite Element Analysis Study of the Influence of the Elastic Modulus of the Nucleus Pulposus
on the Biomechanical Performance of a Model of a Cervical Spine Motion Segment.