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This finding also govern that pathognomonic Negri bodies could only be seen in 20 to 60% of rabies infected cases (Woldehiwet, 2005) and further, histopathological analysis could not be set as tentative diagnostic test for rabies as compared with immune histochemistry (Stein et al.
The difference in viral N gene expression and FAT pattern suggests that viral RNA distribution may differ among rabies variants being possibly related to the ability of hijacking TLR3 to inside the Negri bodies and thus promoting higher level of viral replication.