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In the vegetal posterior quadrant, the cells with endodermal fate express Lhx3/4 at the 32-cell stage and Nkx2-1 at the 64-cell stage under the control of maternal [beta]-catenin.
Woo et al., "Integrated cistromic and expression analysis of amplified NKX2-1 in lung adenocarcinoma identifies LMO3 as a functional transcriptional target," Genes & Development, vol.
Transgenic mice carrying deletions of Pten and TP53 [[Pten, p53].sup.(thyr-/-)] develop ATC with loss of expression of the thyroid transcription factors, Nkx2-1, Pax-8, and Foxel, and thyroid differentiation markers, Nis, Tpo, Tg, Tshr, and Duox [16].
A set of proteins regulated by Nkx2-1 [NK2 homeobox 1 (Titf1)], a master transcription factor in cells from the peripheral airways and a known lineage-survival oncogene in lung cancer, was identified in plasmas of mouse models of lung adenocarcinoma.
Researchers from Boston University School of Medicine (BUSM), engineered mouse embryonic stem cells cultured in the lab to express a genetic switch for a specific gene, Nkx2-1, that is important for thyroid development.
The RNAscope 2.5 HD BROWN assays (Advanced Cell Diagnostics [ACD], Hayward, California) were performed using target probes to napsin A and TTF-1 (NKX2-1) on TMA slides containing 80 cases of lung ACA, 80 cases of lung SCC, and 220 nonpulmonary carcinomas/ACAs, according to the manufacturer's instruction.
SCGB3A2 was originally identified as a downstream target for the homeodomain transcription factor NKX2-1, one of the critical transcription factors responsible for the development of lung and lung-specific expression of genes [3, 5, 23-25].