cell

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Related to NK cell: mast cell, B cell, T cell

cell

an independent team of operatives who work together in a CELLULAR MANUFACTURING production environment.
References in periodicals archive ?
Herewith, we showed that intravenous application of MSCs in tumor-bearing mice significantly suppressed systemic antitumor immune response, reduced total number of lung-infiltrated DCs, macrophages, CD4+ T lymphocytes, CTLs, and NK cells, and attenuated antitumor cytotoxicity of CTLs and NK cells resulting with the expansion of metastatic lesions in the lungs.
To inhibit NK cell activity, antiasialo-GM1 mouse antibody (014-09801) and normal rabbit IgG (control mouse antibody: 148-09551) were purchased from Wako Pure Chemical Ind.
Primary mediator of tissue damage is excessive cytokine production by NK cells, macrophages and CTLs.2 Cytokines found at extremely high levels in the plasma of patients with HLH include interferon gamma (Ifn-g); tumor necrosis factor alpha (TNF-a); IL-6, IL-10, and IL-12; and the soluble IL-2 receptor (CD25).8-10
By building on our knowledge of the activating receptor NKp46, we have generated a technology to specifically induce tumor killing by NK cells. This new technology platform is complementary to our innovative portfolio of first-in-class antibodies targeting immune checkpoints.
Since the immune system is a reticular and syntrophic entirety, NK cell dysfunction also influences the function of the other parts of the system, especially effector T cells.
GTB-3550 (OXS-3550) is the Company's first Tri-specific NK cell Engager (TriKE) product candidate being initially developed for the treatment AML.
In this way, the scientists also discovered that FRIZZLED, a known signal receptor for CAR NK cell therapy, is not as effective as a target as was originally assumed.
After nutrient application, the function of NK cells, TNF-a and receptor levels were measured by phytohemagglutinin (PHA) and ELISA.
To reach this conclusion, physicians devised a mathematical formula unlocking the complex interactive relationship between externally introduced viruses and NK cells in addition to the immune system's existing NK cells to calculate cancer cell-killing potency.
To investigate the changes in the immune system in term normal pregnancy, we first analyzed the subtypes of NK cells in peripheral blood and decidua during normal pregnancy; then, we analyzed the expression of NCRs on the CD56+CD3- NK cell; and, finally, we evaluated cytokine production in the peripheral blood and decidua in term pregnancy.
Studies have shown that the inhibition of immune function by stress response is caused by inhibition of natural killer cell (NK cell) function.