5 minimum alveolar concentration
isoflurane in 60% oxygen protected human peripheral blood mononuclear cells against in vitro sepsis induced by lipopolysaccharide or by plasma from septic patients
Hospital stay and mortality are increased in patients having a "triple low" of low blood pressure, low bispectral index, and low minimum alveolar concentration
of volatile anesthesia.
The variables examined were: 1) EEG parameters (SE, SLA, delta power) from the midpoint of surgery and 10 minutes before wakening; 2) drug effects (the mean age adjusted minimum alveolar concentration
, calculated effect-site morphine concentrations at the end of surgery); 3) demographic variables (age, gender); and 4) estimated surgical trauma (operation duration and surgical trauma score).
General anaesthesia was induced with inhalation of sevoflurane 8% in a mixture of oxygen and nitrous oxide (30:70%) and maintained with 1 minimum alveolar concentration
of sevoflurane and an inspiratory oxygen fraction of 0.
5 to 1 minimum alveolar concentration
and propofol infusion 2 to 4 mg.
A representative patient from this group was a 32-year-old, 104 kg woman who received a total dose of rocuronium of 100 mg over a 150 minute operative procedure during which 1 minimum alveolar concentration
isoflurane had been used as part of a balanced anaesthetic.
A] is related to the clinical end-points of immobility and hypnosis as described by minimum alveolar concentration
(MAC) and MACawake 'concepts', respectively (2,3).