The 0.5 minimum alveolar concentration
isoflurane in 60% oxygen protected human peripheral blood mononuclear cells against in vitro sepsis induced by lipopolysaccharide or by plasma from septic patients
After a period of time in which the partial pressure of sevoflurane in the brain would have equilibrated with the alveolar partial pressure (6,7), the patient showed clinical signs of adequate anaesthesia and had an end-tidal sevoflurane concentration of more than 1 minimum alveolar concentration
, but the entropy monitor still indicated an awake state.
After intubation, ventilation was gently assisted and anaesthesia was maintained with age-adjusted 0.5 minimum alveolar concentration
(12) end-tidal sevoflurane and 50% nitrous oxide and 50% oxygen.
Propofol seems to cause a lesser reduction in uterine contractility than the volatile anaesthetics, because sevoflurane causes a decrease in contractility to 50% of control at 0.94 minimum alveolar concentration
and at 3.5 minimum alveolar concentration
it abolishes all uterine activity (7).
Several studies have shown a decreased maternal minimum alveolar concentration (MAC) for inhalational agents during pregnancy (1-3).
Minimum alveolar concentration of halothane and enflurane are decreased in early pregnancy.
Estimates of effect-site levels should be similar to minimum alveolar concentration (MAC) values, which are determined after allowing time for equilibrium.
Various measures of anaesthetic potency based on the concept of minimum alveolar concentration (MAC) (2) have been described.