Twenty adult female Wistar rats with SCI were randomly divided into two the following two groups: 1) Group A: activated microglial cell
transplantation group, n=10; 2) Group B: a sham-operated control group that received a normal saline injection, n=10.
Glass, "Microglial cell
origin and phenotypes in health and disease," Nature Reviews Immunology, vol.
Lee, "Tryptanthrin suppresses the activation of the LPS-treated BV2 microglial cell
line via Nrf2/HO-1 antioxidant signaling," Frontiers in Cellular Neuroscience, vol.
Just like the other macrophages in the body, microglial cells
act by a cytotoxic and phagocytosis mechanism on foreign bodies; they also play an antigen role by maintaining homeostasis by cytokine secretion (3).
In brain,theincreased microglial cells
resulted into the formation of microglial nodules, while in lungs alveolar septa was widened with increased infiltration of the inflammatory cells including macrophages.
In this study, we demonstrated baicalin attenuated brain injury after SAH in multistep mechanisms including microglial cell
activation, inflammation, modulation of blood-brain barrier function, and oxidative damage.
The two-step activation process of microglia during autoimmune inflammation in CNS required CD40 expression on microglial cells
Clq is a member of the complement cascade, a group of immune system proteins that calls in microglial cells
to gobble up synapses or cells.
The present study demonstrates that a self-referencing microsensor can detect [H.sub.2][O.sub.2] changes in the nano-molar range near the surface of a single microglial cell
. Though numerous assays are available to measure an oxidative burst within macrophages, the self-referencing technique is unique in providing the ability to measure the microenvironment around a single cell or cluster of cells in real-time and with high spatial and temporal resolution.
Salvi, "An immortalized microglial cell
line (Mocha) derived from rat cochlea," Molecular and Cellular Neurosciences, vol.
The immortalized BV2 murine microglial cell
line and rat pheochromocytoma PC12 neuronal cell line were obtained from the Cell Culture Center of the Chinese Academy of Medical Sciences (China).
The PI3K/Akt pathway is required for LPS activation of microglial cell
. Immunopharmacology and Immunotoxicology 34, 858-865.