Wu G, Datar RH, Hansen KM, ThundatT, Cote RJ, Majumdar A (2001) Bioassay of prostate-specific antigen (PSA) using microcantilevers
This has several advantages: the specific surfaces of the microcantilevers
is increased significantly; titanium dioxide binds well to substances that contain nitro groups, which are characteristic of TNT and other explosives; and the tubes have an open structure, which improves the movement of mass and ensures a rapid sensor response.
In the absence of higher order material surface properties, the dilations experienced by the bitumen droplets in the microcantilever
experiments are about five percent for typical droplet axial extensions (Figure 7).
The biochip utilizes arrays of microcantilevers
with customizable surfaces to detect interactions between proteins, antibodies, antigens, or DNA.
The underlying concept is based on micro-scale resonators that are similar to microcantilevers
used in atomic force microscopy, which has recently been explored as mass and force sensing devices.
We have used microcantilever
arrays to investigate drug resistance in superbugs such as MRSA, and are excited by the opportunity to extend this approach to detecting HIV markers," she said.
Such data would allow microcantilever
sensors to be designed to a given specified level of selectivity, sensitivity, and robustness.
The researchers measure the amount of bending by bouncing a laser beam off the microcantilever
and measuring the deflection.
To investigate this problem, Raman and fellow researcher, Shuiqing Hu, deliberately caused chaotic oscillations by making adjustments to the forces exerted by the AFM's piezoelectric crystal and increasing the amplitude of the microcantilever
by specific amounts.
It was recently shown that when such specific biomolecular reactions occur between receptor and target molecules on one surface of a microcantilever
, the cantilever bends.
technology, licensed exclusively from Oak Ridge National Laboratory (ORNL)," he continues, "lets us build our detectors without the need for special materials and processes, and that will have major implications for volume production and cost.
In this case, the microcantilever
is set into a fixed oscillatory mode that is altered when hybridization between PCR-derived DNA and its cognate oligonucleotide probe takes place (Fig.