Fuller et al., "A comprehensive review of the treatment of Merkel cell
carcinoma," The American Journal of Clinical Oncology, vol.
Of this group, 64% had tumors positive for the Merkel cell
polyomavirus and 49% had PD-Ll expression on tumor cells.
"The overall impressive results show that this form of immunotherapy is quite effective, giving us an important treatment option for patients with Merkel Cell
Carcinoma that has spread within the body."
Histological appearance suggests small cell undifferentiated Merkel Cell
carcinoma, confirmed through IHC with positive values of approximately 80% for Ki67, diffusely positive values for Synaptophysin, Chromogranin A and CK20 in tumor cells with a paranuclear dot-like granule.
carcinoma: A report of 34 cases and literature review.
Clinical activity was observed across all patient subgroups, irrespective of PD-L1 expression in tumor tissue or Merkel cell
Case reports of Merkel cell
carcinoma and Kaposi's sarcoma of the skin have been reported in the setting of Adalimumab therapy.
The viruses that are associated with cancers include hepatitis B and C viruses (HBV and HCV), human papilloma viruses (HPV), human T-cell leukemia virus (HTLV-1), human immunodeficiency virus (HIV), Epstein-Barr virus (EBV), human herpes virus 8 (HHV-8) which is also known as Kaposi sarcoma-associated herpes virus (KSHV), and Merkel cell
Tumours of neural origin include paragangliomas and Merkel cell
carcinoma of the integument.
carcinoma (MCC) is a rare and highly aggressive cutaneous malignancy, also known as "primary neuroendocrine carcinoma of the skin." MCC occurs most often on the sun-exposed face, head, and neck, with an annual incidence of 1200 new cases each year in the US, which is far less than other forms of skin cancers and has a 2: 1 predominance in males .
Skin Receptor Frequency Meissner corpuscle 1-300 Hz Glabrous skin Merkel cell
0-100 Hz Free nerve ending 0-8 Hz Pacinian corpuscle 5-1000 Hz Hairy skin Merkel cell
Hair flattening Skin Nerve Modality A[beta](RA1-LTMR) Stroking Fluttering Glabrous skin A[beta](SA1-LTMR) Pressure Texture -- -- A[beta](RA2-LTMR) Vibration Hairy skin A[beta](SA1-LTMR) A[delta] (SA1-LTMR) RA: rapid adaptation; SA: slow adaptation; LTMR: low-threshold mechanoreceptor.
carcinoma (MCC) is a rare, highly aggressive, primary cutaneous neuroendocrine carcinoma affecting older individuals and immunosuppressed patients and often presents as an erythematous or violaceous papule, nodule, or plaque on the skin of the head and neck or extremities.