While investigating for probable clues to suggest TB, it has been evident that in some patients, the Mantoux test
and CSF TB-PCR can become negative.
demonstrated an induration of 28 mm at the end of 72 hours (N < 10 mm).
Tuberculosis may present with pancytopenia, features of hemophagocytosis in bone marrow, and negative Mantoux test
does not rule out the diagnosis.
Though it is well established that Mantoux test
should not be used as a diagnostic tool in adults still 16(31.4%) clinicians felt that Mantoux test
result can be considered for initiating treatment.
Kumar et al3 and Pandhi et al8 have observed very high rates of Mantoux test
positivities in their
Screening for TB involves a simple skin test - a Mantoux test
- which is examined two to three days later and will show whether someone has been exposed to the TB germ.
Routine biochemical and hematological investigations, Mantoux test
and chest X-rays were done for all patients.
The diagnosis of PTB/HIV co-infection was based on criteria for diagnosing TB in poor resource settings where there are no facilities and manpower for mycobacterium tuberculosis culture: (a) the diagnostic criteria of TB given in the World Health Organisation (WHO) treatment of tuberculosis guideline for national programmes ; (b) specificity of clinical criteria in diagnosing TB patient [6, 10]; (c) Although Mantoux is usually negative in HIV infection because of loss of cell mediated immunity due to depletion of CD4 count, HIV patients who were smear negative for AAFB, but had positive Mantoux test
with an area of induration [greater than or equal to]10mm diameter were considered diagnostic for tuberculosis.
The aim of this study is thus to highlight any cases of tubercular infection in order to measure the performance of two tests: Mantoux test
and an in vitro assays (T-SPOT-TB).
The USPSTF recommendation to screen asymptomatic high-risk children for TB is based on the effectiveness of early intervention (14 controlled trials) and the accuracy of the Mantoux test
Children with a positive mantoux test
are referred to the Children's TB clinic at Starship Hospital.
PASSAR screens, level-of-care verification, physicians' orders, and Mantoux test
results for tuberculosis are just a few examples of required documentation, some of which can significantly affect payment if not obtained properly.