Since then, the proteolytic activity of
MALT1 has appeared as a promising target for treatment of auto-immune disorders and certain types of cancer.
Neither API2 nor
MALT1 alone can cause a ripple effect on NIK.
Various known tumor-associated genes (bcl2,
MALT1 and DCC at 18q21; and RAP1 at 4q21) and a gene related to the embryogenesis of gonads such as H-Y regulator gene at Xp22.
4) The t(11;18)(q21;q21) chromosomal translocation, resulting in the production of a fusion protein composed of the apoptosis inhibitor API2 on chromosome 11q21 and the paracaspase
MALT1 on chromosome 18q21, is the most common structural abnormality identified in the primary pulmonary MZL.
14-17,19-21,110,118,119) The most common translocation in gastric MALT lymphoma arising in approximately 20% to 30% of cases (although at a lower rate in North America) is t(11;18)(q21;q21), which fuses the amino terminal of the API2 gene (that encodes the inhibitor of apoptosis) at 11q21 to the carboxyl terminal of
MALT1 at 18q21, leading to a chimeric fusion product.
