(b) Genome-wide LOD score
plot of single-QTL scans for plasma TG concentrations (solid lines: cross direction as an additive covariate; broken lines: cross direction and body weight as additive covariates).
The peak LOD score
for [a.sup.*] and [b.sup.*] on GGA 24 occurred at the BCDO2 locus, an obvious candidate gene for shank skin color variations (Eriksson et al., 2008).
Genome-wide genotyping, haplotyping, and fine mapping linked renal Hg accumulation to three genes with identical LOD scores
of 1.94: Btrc, Pprc1, and Nfkb2.
In this study, we used, for the first time, LOD score
linkage analysis to identify loci that contribute to the expression of the microvascular complications of RET and NEPH.
Two-point LOD scores
between the disease phenotype and markers in this region are summarized in Figure-1B.
El gen IL13RA3 esta localizado en el cromosoma Xq13.1-q28, donde se han descrito ligamiento con LOD score
mayor a 2 y alteraciones citogeneticas (60, 61); por lo que han sido postulados otros genes candidato como los genes de las neuroliguinas 3 y 4 (NLGN3 o Neuroligin 3) (25).
Nine of the distorted markers (TUMXLv9.28, 5.38, 9.43, 6.3, 9.93, L29.2, 10.208, 10.255, and 10.323) located on to LG4 using LOD score
of 3.0 (Fig.
TABLE 1 Characteristic Value Mean (95% confidence interval) Age, years 66.2 (62.5-69.9) APACHE II score 27.6 (26.2-29.1) LOD score
8.2 (7.7-8.7) SOFA score 11.1 (10.3-11.9) Platelet count, x[10.sup.9]/l 198.7 (162.2-235.3) Creatinine, mg/dl 2.7 (2.2-3.2) Lactate, mmol/l 4.1 (3.2-4.9) Albumin, g/dl 2.4 (2.3-2.6) Number of ICU days 15.1 (11.3-19) Number (%) Gender Male 34 (49.3) Female 35 (50.7) Source of sepsis Pneumonia 26 (37.7) Urinary tract infection 16 (23.2) Skin/decubiti 9 (13) Intra-abdominal 5 (7.3) Central nervous system 3 (4.4) Unknown 10 (14.5) Thrombocytopenia Total 38 (55) Mild 8 (11.6) Moderate 11 (15.9) Severe 6 (8.7) Very severe 13 (18.8) Mortality rate 38 (55) Characteristics of study patients (n=69) TABLE 2 Cause No.
The linkage analyses are repeated for various values of [Theta] and results are reported as the logarithm of the odds of likelihood of linkage, or lod score
, for each family and summed for the total families.
The linkage map was generated from the data using MAPMAKER 3.0b with a LOD score
Thus, the maximum (i.e., peak) LOD score
for these markers was 2.5 in the initial sample and 1.6 in the replication sample, suggestive of genetic linkage.
The chromosomal location with the highest LOD score
(linkage odds score) is marked as the most likely location for a QTL affecting the trait.