In this study, we identified two novel heterozygous variants in the LHCGR gene (c.349G>A, p.Gly117Arg and c.878C>A, p.Ser293 (*)) causing type 1 Leydig cell
hypoplasia in a 2.75 year old patient presenting with female external genitalia and bilateral testis tissue in the inguinal region.
Control group Table 3: The number of different testis cell types (x[10.sup.6]) Groups Spermatogonia A Spermatogonia B Sertoli cell Control 0.83[+ or -]0.06 0.16[+ or -]0.07 2.7[+ or -]0.2 BD1/2 0.83[+ or -]0.05 0.13[+ or -]0.05 2.5[+ or -]0.1 BD1/4 0.84[+ or -]0.05 0.18[+ or -]0.05 2.7[+ or -]0.3 Groups Primary Round Long spermatocyte spermatid spermatid Control 12.1[+ or -]0.98 31.8[+ or -]2.49 30.9[+ or -]3.02 BD1/2 12.0[+ or -]0.80 31.0[+ or -]2.18 30.6[+ or -]2.66 BD1/4 12.4[+ or -]0.92 32.2[+ or -]2.20 32.1[+ or -]2.65 Groups Leydig cell
Control 2.2[+ or -]0.02 BD1/2 2.5[+ or -]0.15 (**) BD1/4 2.1[+ or -]0.03 The values (n=5) are presented as mean[+ or -]SD.
Role of P2-purinergic receptors in rat Leydig cell
Immunohistochemical analysis revealed that the StAR was exclusively localized in Leydig cell
of the interstitial compartment, even though non-specific immunostaining of STAR was often found within the seminiferous tubules, especially acrosomal regions of spermatozoa (Figure 3C, Table 3).
Variation in the circumtesticular Leydig cell
tunic of teiid lizards (Cnemidophorus and Ameiva).
Other ovarian tumors include steroid cell tumor, ovarian luteoma, and Leydig cell
There is still debate concerning the carcinogenesis of primary testicular carcinoid tumors since the presence of NE cells in the testis has not been yet described with hypotheses postulating the origin to be the same precursor cell as Leydig cells
, while others attributing it to a chromosomal abnormality [7, 13].
In adult rat Leydig cell
cultures, both retinol and retinoic acid-enriched media showed a direct stimulatory effect on testosterone biosynthesis via 3[beta]-HSD compared to control media, as measured by radioimmunoassay.
Theophylline, a caffeine metabolite and pharmaceutical used in the treatment of asthma had previously been shown to impair Leydig cell
development in the rat (Pollard et al.
The study is the first to report a method for generating Leydig cells
by means of direct cell reprogramming.
Cecchetto et al., "Ovarian Sertoli Leydig cell
tumours in children and adolescents: an analysis of the European Cooperative Study Group on pediatric rare tumors (EXPeRT)," European Journal of Cancer, vol.
Zirkin, "Leydig cell
aging and the mechanisms of reduced testosterone synthesis," Molecular and Cellular Endocrinology, vol.