In this study, we identified two novel heterozygous variants in the LHCGR gene (c.349G>A, p.Gly117Arg and c.878C>A, p.Ser293 (*)) causing type 1
Leydig cell hypoplasia in a 2.75 year old patient presenting with female external genitalia and bilateral testis tissue in the inguinal region.
Control group Table 3: The number of different testis cell types (x[10.sup.6]) Groups Spermatogonia A Spermatogonia B Sertoli cell Control 0.83[+ or -]0.06 0.16[+ or -]0.07 2.7[+ or -]0.2 BD1/2 0.83[+ or -]0.05 0.13[+ or -]0.05 2.5[+ or -]0.1 BD1/4 0.84[+ or -]0.05 0.18[+ or -]0.05 2.7[+ or -]0.3 Groups Primary Round Long spermatocyte spermatid spermatid Control 12.1[+ or -]0.98 31.8[+ or -]2.49 30.9[+ or -]3.02 BD1/2 12.0[+ or -]0.80 31.0[+ or -]2.18 30.6[+ or -]2.66 BD1/4 12.4[+ or -]0.92 32.2[+ or -]2.20 32.1[+ or -]2.65 Groups
Leydig cell Control 2.2[+ or -]0.02 BD1/2 2.5[+ or -]0.15 (**) BD1/4 2.1[+ or -]0.03 The values (n=5) are presented as mean[+ or -]SD.
Role of P2-purinergic receptors in rat
Leydig cell steroidogenesis.
Immunohistochemical analysis revealed that the StAR was exclusively localized in
Leydig cell of the interstitial compartment, even though non-specific immunostaining of STAR was often found within the seminiferous tubules, especially acrosomal regions of spermatozoa (Figure 3C, Table 3).
Variation in the circumtesticular
Leydig cell tunic of teiid lizards (Cnemidophorus and Ameiva).
Other ovarian tumors include steroid cell tumor, ovarian luteoma, and
Leydig cell tumor.
There is still debate concerning the carcinogenesis of primary testicular carcinoid tumors since the presence of NE cells in the testis has not been yet described with hypotheses postulating the origin to be the same precursor cell as
Leydig cells, while others attributing it to a chromosomal abnormality [7, 13].
In adult rat
Leydig cell cultures, both retinol and retinoic acid-enriched media showed a direct stimulatory effect on testosterone biosynthesis via 3[beta]-HSD compared to control media, as measured by radioimmunoassay.
Theophylline, a caffeine metabolite and pharmaceutical used in the treatment of asthma had previously been shown to impair
Leydig cell development in the rat (Pollard et al.
The study is the first to report a method for generating
Leydig cells by means of direct cell reprogramming.
Cecchetto et al., "Ovarian Sertoli
Leydig cell tumours in children and adolescents: an analysis of the European Cooperative Study Group on pediatric rare tumors (EXPeRT)," European Journal of Cancer, vol.
Zirkin, "
Leydig cell aging and the mechanisms of reduced testosterone synthesis," Molecular and Cellular Endocrinology, vol.