Quercetin also improved lipid metabolism by regulating SREBPs and LDLR
protein expression, which are controlled by Akt.
Native LDL is endocytosed into the cells through the LDLR
and probably generates ROS to induce cellular senescence via both p53 and p16-pRb signal transduction pathways.
Lowdensity lipoprotein receptor gene (LDLR
) world-wide website in familial hypercholesterolemia: update new features and mutation analysis.
In these cases, forty two cases were found high LDL-C, xanthelasmas, tendon xanthomas and arcus cornea with exons 3, 4 mutation of LDLR
Si bien en la propuesta original se sugeria el analisis de tres marcadores geneticos (D1S80, D17S49 y Apo B), algunos de estos fueron reemplazados por los siete marcadores geneticos "convencionales" (D1S80, HLA-DQA1, LDLR
, HBGG, GYPA, D758 y Gc) debido a la disponibilidad comercial de los reactivos, decision que a la larga fue acertada, pues significaba estar implementando en Costa Rica los mismos marcadores geneticos que se estaban utilizando en los paises desarrollados en el campo de la genetica forense, y abria las puertas a la posibilidad de acreditacion de la calidad analitica en el contexto internacional.
It has been demonstrated by many previous articles that LDL anchored toward the surface of the DDS can target LDLR
(30,31), which is excessively expressed in various cancer cells, including liver cancer (14).
Clearance of VLDL from the plasma by the LDLR
is mediated by apoE, but chylomicron remnant clearance is more complex.
SREBP is known to modulate the regulation of ANGPTL3, LDLR
, and PCSK9, all of which affect the plasma lipids profile [8, 9].
Isoniemi, "Transmission of LDLR
mutation from donor through liver transplantation resulting in hypercholesterolemia in the recipient," American Journal of Transplantation, vol.
Lipid metabolism abnormalities, elevated low-density lipoprotein (LDL) and triglyceride levels, and/or reduced high-density lipoprotein (HDL) levels are known to be heavily involved in the genesis and progression of atherosclerosis in humans in which type-IIa hypercholesterolemia is frequently observed, with elevated plasma LDL-cholesterol (LDL-C) due to reduced efficiency or lack of the LDL receptor (LDLr
The RGX-501 is a novel therapy to cure homozygous familial hypercholesterolemia (HoFH) that utilizes the NAV rAAV8 vector to provide the human low-density lipoprotein receptor (LDLR
) gene to the liver cells.
Finally, the mRNA levels encoded by the genes for the low-density-lipoprotein receptor (LDLR
), the sterol-regulatory-element-binding transcription factor (SREBF2), the very-low-density-lipoprotein receptor (VLDLR), and the acetyl-CoA carboxylase (ACACA) were determined by real-time RT-PCR.