Efficacy of the L-selectin
antagonist was evaluated by measuring its ability to affect human lymphocyte trafficking in SCID mice.
, one of the family members, is found on the surface of most leukocytes.
3- To investigate whether leukocytes from L-selectin
tail serine-to-alanine knock-In mice exhibit impaired adhesion and migration in vivo.
Expression of L-selectin
(CD62L), CD44, and CD25 on activated bovine T cells.
Sulfated sialyl Lewis X, the putative L-selectin
ligand, detected on endothelial cells of high endothelial venules by a distinct set of anti-sialyl Lewis X antibodies.
These results suggest that L-selectin
mediates interactions with the uterus and that this adhesion mechanism may be critical to establishing human pregnancy," Fisher said, according to the Times.
When Fisher and researchers at a fertility clinic examined unused human embryos donated for research, they found that human trophoblasts make L-selectin
has been defined as a neutrophil-rolling and lymphocyte-homing receptor (14,15).
The other molecules -- plasminogen activator inhibitor-1, E-selectin, L-selectin
and P-selectin -- are often elevated in people with metabolic and cardiovascular disease.
Intercellular adhesion molecule-1 (ICAM-1) and E-, P-, and L-selectin
are cellular adhesion molecules involved in the recruitment of leukocytes on the activated vessel wall during inflammation (1) and play an important role in the early stages of atherosclerosis and its complications (2).
is a molecule which mediates the first step in this process -- the binding of neutrophils to the endothelial lining of blood vessels -- and the SMART Anti-L-Selectin
Antibody is expected to interfere with this binding.
Following intravenous administration, Heparinase III cleaves HS binding sites for L-selectin
, P-selectin, and chemokines that are expressed or released during ischemia/reperfusion, allowing them to be swept away in the blood stream.