The rolling frequency is largely determined by P-selectin, with E-selectin playing a smaller role, and L-selectin
is not involved.
Identification of new proteins binding to L-selectin
tail and understanding the mechanisms controlling this interaction is essential for the design of new therapeutic strategies for the treatment of inflammatory and auto-immune diseases.
Sulfation-dependent recognition of high endothelial venules (HEV)-ligands by L-selectin
and MECA 79, and adhesion-blocking monoclonal antibody.
We used this system to examine whether AFA-W would compete with fucoidan for binding to L-selectin
on the leukocyte cell surface and to assess whether it would block the externalization of CXCK4 triggered by fucoidan.
Fisher and her colleagues also showed that an antibody to L-selectin
inhibited lab-grown trophoblasts from binding to uterine tissue harvested during the window of receptivity.
has been defined as a neutrophil-rolling and lymphocyte-homing receptor (14,15).
The purpose of the present study was to establish age-and sex-specific reference intervals for serum concentrations of soluble ICAM-1 and E-, P-, and L-selectin
in healthy children (4-17 years) and adults (18-55 years).
The aptamer binding to L-selectin
on cells showed a 20-fold affinity improvement upon dimerization.
, one of the family members, is found on the surface of most leukocytes.
Director of Inflammation Research at NeXstar Pharmaceuticals, discussed the development of a high affinity oligonucleotide that binds to L-selectin
in vivo, one of three members of a family of cell adhesion molecules involved in the early stages of inflammation.
For example, The Company's antagonist of L-selectin
has, to date, been shown to inhibit L-selectin
-mediated lymphocyte trafficking, a process thought to play a role in triggering certain adverse inflammatory responses.
Glycomimetics' lead compound, GMI-1070, is a rationally-designed glycomimetic inhibitor of E-, P- and L-selectins
, and inhibits a key early step in the inflammatory process leading to leukocyte adhesion and recruitment to inflamed tissue.