KIR mismatch was only present in 11/16 donor/recipient pairs.
In addition, there was no association between specific NK phenotype, effector function, KIR mismatching, or circulating [CD56.sup.+] cell number postinfusion and response.
Five patients achieved a morphologic CR, including 75% of those with KIR mismatch versus 13% of those without.
Interestingly, no differences in toxicities or survival endpoints were noted based on KIR mismatching or donor activation of KIR.
In conclusion, we demonstrated that Juzen-taiho-to upregulated the expression of KIRs. These effects contribute to the augmentation of NK cytolytic activity, and might explain, in part, its antitumor effects which were observed in vivo (Hamada et al., 1988; Ohnishi et al., 1996; Ohnishi et al., 1998; Horie et al., 1992).
Abbreviations: CD, clusters of differentiation; KIR, killer-cell immunoglobulin-like receptor; MHC, major histocompatibility complex; NK, natural killer; IL, interleukin; IFN, interferon
To further refine programs for those at highest risk of unresectable HCC, we explored the association between KIR locus, HLA ligand, and HLA-KIR combination with the TNM stages of HCC at diagnosis.
To our knowledge, this is the first report on the association between KIR and HLA genetic background and the onset age of HCC.
Romagne, "NK cell MHC class I specific receptors (KIR): from biology to clinical intervention," Current Opinion in Immunology, vol.
Sun et al., "KIR and HLA loci are associated with hepatocellular carcinoma development in patients with hepatitis B virus infection: a case-control study," PLoS ONE, vol.