According to cDNA library and existing research reports, we designed and synthesized the primers of KCNE1 and KCNE3 genes based on the KCNE1 and KCNE3 exon's gene sequence.
KCNE1 has several transcripts in humans, and the last exon of KCNE1 is already known to participate in encoding proteins.
3) and the 45-bp fragment of
KCNE1 (see online Supplemental Fig.
Lin et al., "Relevance of gene
KCNE1 and lone atrial fibrillation," Shanghai Medical Journal, vol.
Upregulation of
KCNE1 Induces QT Interval Prolongation in Patients with Chronic Heart Failure.
Professor Guy Van Camp, who led the research said, 'Further studies on
KCNE1 show the version of the gene associated with increased risk to noise causes the encoded ion channel to open more rapidly than the normal version.
There is evidence of a heritable contribution to LAF, where a polymorphism (S38G) in Mink (
KCNE1) was associated with nonfamilial AF [13] (the sporadic LAF).
The remainder may have mutations in
KCNE1 or KCNE2 encoding minx (8) and MiRP1 (4), respectively, or in the SCN5A gene encoding the SCN5A [Na.sup.+]-ion channel conducting the [I.sub.Na] current responsible for the initial depolarization of the action potential (9,10).
minK (IsK or
KCNE1) was initially localized to chromosome 21 (21q22.1) and found to consist of 3 exons that span approximately 40 kb.
