Total glucosides of paeony promote intestinal motility in slow transit constipation rats through amelioration of interstitial cells of cajal
. PloS One 2016, 11: e0160398, doi: 10.1371/journal.pone.
Prior studies have primarily focused on mast cells, histiocytes, smoothelin, interstitial cells of Cajal
, and neural tissue.
To reveal the effects of interstitial cells of Cajal
in the contractions, %Decrease was employed to evaluate the cell number of interstitial cells of Cajal
However, accumulating evidence supports the presence of structural and functional alterations in the ENS of the entire GI tract and the interconnections with enteric glial cells and interstitial cells of Cajal
. This explains the biochemical, immune-mediated, and inflammatory pathophysiological mechanisms, which coalesce in the development and maintenance of cell death, altered secretion of neurotransmitters, dysmotility, and concomitant symptoms in the entire length of the GI tract.
The proposed cellular origin of GISTs are the interstitial cells of Cajal
, intestinal pacemaker cells that regulate autonomous contraction of the GI tract .
Key words: Hirschsprung's disease, Interstitial cells of Cajal
, enteric nervous system.
Farrugia, "Physiology, injury, and recovery of interstitial cells of Cajal
: basic and clinical science," Gastroenterology, vol.
Sanders, "Pacemaker potentials generated by interstitial cells of Cajal
in the murine intestine," American Journal of Physiology-Cell Physiology, vol.
The interstitial cells of Cajal
or related stem cell-like precursors are positive for CD34 or CD117 in the immunohistochemical staining.
Because GISTs share CD117 positivity with the interstitial cells of Cajal
, they were assumed to originate from that cell type.
(2010) reported a reduction of interstitial cells of Cajal
in the gastric muscle layer in the diabetic mice.
Nowadays, GISTs may be defined as morphologically spindle cells, epithelioid cells, or occasional pleomorphic mesenchymal tumors originating from interstitial cells of Cajal
or related stem cell expressing CD-117/C-kit protein in 95% of the cases regardless of the site of origin, histological appearance, and biological behavior.