The overall response rate (ORR) was 48% and PFS 13 months.Toxicities were mild and the efficacy was comparable to the cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP) chemotherapy regimen, then considered as the gold standard for indolent lymphomas
. This study led to approval of rituximab for relapsed indolent NHL in 1997 (21).
* The report reviews key players involved in the therapeutics development for Indolent Lymphoma
and enlists all their major and minor projects
In contrast, patients with follicular and other indolent lymphomas
can sustain prolonged remission periods, but eventually relapse and require subsequent courses of therapy that lead to fewer and shorter remissions .
Based on the European Society for Medical Oncology (ESMO) guidelines, inhibition of the PI3K pathway has been shown to be an effective therapeutic strategy in treating indolent lymphomas
, like follicular lymphoma; however, concerns exist about the safety of available oral PI3K inhibitors, highlighting the need for new approaches, said Martin Dreyling, Professor of Medicine at the University of Munich Hospital in Grosshadern.
Bendamustine Plus Rituximab Is Superior in Respect of Progression Free Survival and CR Rate When Compared to CHOP Plus Rituximab as First-Line Treatment of Patients with Advanced Follicular, Indolent, and Mantle Cell Lymphomas: Final Results of a Randomized Phase III Study of the StiL (Study Group Indolent Lymphomas
, Germany) Blood (ASH Annual Meeting Abstracts) 2009 Nov;114:405.