Serum
IGF1 and serum IGFBP3 levels are identified to positively correlate with normal growth rate in children and adolescents and also with aerobic performance in children (Brun et al., 1996; Manetta et al., 2002).
Frequencies of the initial dose and dosing schedule of GH in patients with Turner syndrome among 18 pediatric endocrinology centers in Turkey Initial GH n (%) Growth hormone dosing dose (mg/kg/ schedule week) Fixed dose Growth response n (%) or
IGF1 dependent change in dose n (%) 0.375 12 (66.7%) 3 (16.7%) 9 (50%) 0.350 3 (16.6%) - 3 (16.6%) 0.294 1 (5.6%) - 1 (5.6%) 0.315 2 (11.1%) - 2 (11.1%) GH: growth hormone,
IGF1: insulin-like growth factor 1 Table 4.
Insulin-like growth factor 1 (
IGF1) is a growth factor that plays important role in physiological and metabolic processes in vertebrates (De la Rosa Reyna et al., 2010).
Here, researchers will use a blood-brain barrier-penetrating virus vector to overexpress osteopontin and
IGF1 in most neurons and assess its effects on anatomical and behavioral outcomes aside from the CST.
No changes in
IGF1 were observed during the study in either group.
Human Genes:
IGF1, insulin-like growth factor 1; GHR, growth hormone receptor.
The conditional knock-out of
IGF1 and insulin in mice that were driven by the creatinine kinase promoter of the muscle only survived for 3 weeks after birth due to cardiomyopathy and subsequent heart failure [51].
Based on microarray results and subpathway analyses, four genes (
IGF1, MDM2, STAT1, and RAC1) were identified to play an important role in GCT of bone recurrence [10].
IGF1 was 41.8 ng/ml (<5th percentile); however clonidine-stimulated GH peak was normal (12.8 ng/ml).
Such a hypothesis is also supported by evidences showing that leptin levels are positively correlated with insulin-like growth factor-1 (
IGF1) and IGF1-binding protein 3 (IGFBP3) levels in other systems [24, 25] and recent studies by D'Addio et al.
Patient References Thyroid function TSH 2.7 0.5-4.5 mU/L T4 10.25 4.5-12.5 ([micro]/dL Growth hormone secretion
IGF1 345 106-435 ng/mL (Tanner stage II) IGFBP3 5.0 2.8-6.3 [micro]g/mL (Tanner stage II) Adrenal function Cortisol 530 150-800 nmol/L ACTH 54 8-90 ng/L Prolactin 5 2-18 ng/mL Gonadotrophins FSH 5.0 4.7-9.5 mIU/mL LH 4.3 2.1-13 mIU/mL Gonadal function 1200 310-7200 ng/L Testosterone
IGF1, insulin-like growth factor 1; IGFBP3, insulin-like growth factor binding protein 3; ACTH, adrenocorticotropic hormone.
Dupont, "VISFATIN (NAMPT) improves in vitro IGF1-induced steroidogenesis and
IGF1 receptor signaling through
