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Refusal by a bank to grant credit, usually because of the applicants financial history, or refusal to accept a security presented to complete a trade, usually because of a lack of proper endorsements or violation of rules of a firm.


1. A bank's refusal to grant a line of credit. This often applies to the refusal to grant a mortgage loan to an uncreditworthy person or a business loan to someone without a proper business plan.

2. An investor's refusal to accept a security presented to him/her/it. Reasons for this include suspicion of fraud or improperly filled-out forms.

3. Refusal to provide insurance coverage because the insurance company believes that the claim describes a service or situation that the policy does not cover.


The refusal to accept a security that has been delivered by a customer or broker. A questionable certificate or an improper endorsement are reasons for rejection.
References in periodicals archive ?
Investigators placing pig organs in other animal species have stemmed endothelial cell activation and the resulting hyperacute rejection by depleting a prospective recipient's store of alpha-gal antibodies before the xenotransplant.
The basis of this protocol is that the antibodies that would lead to hyperacute rejection or acute antibody-mediated rejection must be removed from the body, and the immune system must be modulated to reduce the production of the antibody in the future or dampen the immune response to the foreign antigen.
An attempt to eliminate hyperacute rejection with human and baboon antibody in GalT-KO kidney has been tried (Diswall et al.
Organs and cells from these double-knockout pigs will be used in pivotal transplantation studies aimed at testing for elimination of hyperacute rejection and long term survival of these xenografts," the company said.
The stimulus of the immune system is exponentially more intense with the transplantation of genetically unmodified xenografts; hyperacute rejection and graft thrombosis would occur immediately due to the presence of discordant species-specific antibodies.
If it succeeds, however, it will only have overcome the hyperacute rejection.
Such hyperacute rejection results from the presence, at the surface of pig cells, of unique carbohydrate antigens which are not expressed by human cells.
The authors identified five biologic hurdles: hyperacute rejection, acute vascular rejection, accommodation, cellular rejection, and chronic rejection.
Due to the immaturity of the babies' immune systems, the researchers said none experienced hyperacute rejection, and no morbidity was attributable to ABO incompatibility.
Nextran's strategy for preventing this hyperacute rejection includes the use of a column which contains an alpha-galactose carbohydrate manufactured by Cytel which is similar to the carbohydrate found on pig tissues.