Hydrogen breath test
. This test is noninvasive, easily administered, and relatively cost effective for diagnosing impaired lactose digestion.
A response to antibiotics in patients with IBS has been shown to correlate with normalization of the results of lactulose hydrogen breath tests
in previous studies.
In addition, more than half of these self-identified lactose intolerant individuals were not, in fact, lactase deficient, based on a hydrogen breath test
conducted after the lactose challenge.
Genotype LP-Alleles LNP LHBT (C[T.bar]-13910/ (CC-13910 Total Phenotype T[G.bar]-13915) & TT-13915) 1 (TG) 31 32 Symptomatic Positive (LI) (42) 0 10 10 Asymptomatic (LT) 1 (CT) 0 1 Symptomatic Negative (LI) (8) 7 (2CT&5TG) 0 7 Asymptomatic (LT) NHP 2 (TG) 0 2 Symptomatic (LI) TOTAL 11 41 52 LP: Lactase Persistence, LNP: Lactase Non-Persistence, LHBT: Lactose Hydrogen Breath Test
, NHP: Non Hydrogen Producers.
This could include a hydrogen breath test
which involves fasting overnight and then consuming some lactose - if a large amount of hydrogen is present then lactose intolerance is diagnosed.
CBC, chemistry, thyroid function test, stool exam, ultrasonography, hydrogen breath test
, erythrocyte sedimentation rate, and C-reactive protein have all very limited accuracy in discriminating IBS from organic diseases.
The hydrogen breath test
for LI is a simple test that can be performed in a doctors office.
Entenmann et al., "Diagnosing lactose malabsorption in children: difficulties in interpreting hydrogen breath test
results," Journal of Breath Research, vol.