Mueller, "OptiMatch[R]-a universally configurable HLA matching
framework," in 22nd European Immunogenetics and Histocompatibility Conference, pp.
(198) Parents who couple this technology with HLA matching
do so to ensure that the child is compatible for live tissue transfer with another existing family member in need of a transplant.
The third strategy for avoiding immune rejection is HLA matching
; however, the importance of HLA matching
in transplantation varies, depending on what tissue or organ is transplanted.
Positions on this aspect of the procedure reflect differing views of the moral status of embryos and the likelihood that using PGD for HLA matching
will lead to using PGD for other nonmedical indications.
Kamani et al., "National marrow donor program HLA matching
guidelines for unrelated adult donor hematopoietic cell transplants," Biology of Blood and Marrow Transplantation, vol.
And among those with good HLA matching
, having anti-MICA antibodies was associated with poorer organ survival (83.2 percent versus 95.1 percent among those without the antibodies).
It was shown that the methodology predicted DSA formation based on HLA mismatches, the recipients' HLA-DR phenotypes, and their identified permissible HLA mismatches to optimize HLA matching
and to guide donor selection.
While HLA matching
improves the outcome of transplantation (utility), the researchers said it decreases the number of nonwhites who undergo transplantation (equity).
This concept of epitope-based HLA matching
is an alternative method to define the most suitable HLA mismatch for each patient, thereby reducing the risk on donor-specific HLA antibody formation after transplantation and graft failure.
The policy addresses HLA matching
, which measures the immune system compatibility between an organ donor and an individual patient.
Haagenson et al., "High-resolution donor recipient HLA matching
contributes to the success of unrelated donor marrow transplantation," Blood, vol.
Improved leukemia-free survival was associated with better HLA matching
, Karnofsky scores of 90 or more, lower white blood cell counts at diagnosis, age younger than 15 years, and first complete remission duration of at least 6 months.