In addition, the diagnosis of [beta]-thalassemia, HLA matching
, sex, and aneuploidy were analyzed and proved to be accurate.
69) Thus, the implications of a commonly performed IVF procedure dramatically expand in scope when coupled with PGD with HLA matching, as the PGD child donor, recipient, and all non-medically participating family members may be affected either psychosocially or physiologically.
198) Parents who couple this technology with HLA matching do so to ensure that the child is compatible for live tissue transfer with another existing family member in need of a transplant.
13) If the same stem cell line could be induced to produce hematopoietic cells for transplant and the tissue of interest for therapy, the mixed chimerism approach could be used to provide patients with cell-based therapies from stem cells without extensive immunosuppression or the need for HLA matching.
The third strategy for avoiding immune rejection is HLA matching; however, the importance of HLA matching in transplantation varies, depending on what tissue or organ is transplanted.
High resolution HLA matching
associated with decreased mortality after unrelated bone marrow transplantation.
Positions on this aspect of the procedure reflect differing views of the moral status of embryos and the likelihood that using PGD for HLA matching will lead to using PGD for other nonmedical indications.
Although PGD operates negatively by screening and exclusion, its use for HLA matching might set a precedent for positive alteration and gene targeting, as might occur in germline gene therapy, nuclear transfer cloning, enhancement, or other nonmedical purposes.
New studies reveal that HLA matching
can be reduced somewhat without compromising graft function.
The link between HLA matching
and cold ischemia and cadaveric kidney survival has been noted by other investigators.
Improved outcome of renal transplant as a result of better HLA matching
is offset by prolonged cold ischemia times, a finding that adds to the debate over the utility of national sharing of donor kidneys.
Black transplant recipients are more likely than white recipients to have chronic rejection, a finding the authors said may be due to differences in immunologic responsiveness, HLA matching
, or blood pressure control.