Gridlock

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Related to HEY2: HEY1, PubMed

Gridlock

A situation in which a business does not function, or functions ineffectively, due to conflicting orders from management and/or insufficient operating procedures. Gridlock may occur when two or more parties are attempting to control a business, or when project goals are incompletely defined because of incompetent management. Gridlock can be very costly to a business' operations, especially when it is prolonged.
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Specific antibodies were used to analyze the following antigens: Notch1, Notch2, Notch3, Notch4, JAG1, DLL4, IL-1R tI, OB-R, Survivin, and Hey2. Tissue sections were deparaffinized, and sodium citrate buffer (pH6, 10mM) was used for antigen retrieval at 95[degrees]C for 30 minutes.
The list of SIRT1 substrates is continuously increasing and includes numerous transcription factors for example: p53, members of the FOXO family, hairy and enhancer of split 1 (HES 1), hairy/enhancer-of-split related with YRPW motif 2 (HEY2) , peroxisome proliferator - activated receptor gamma (PPAR g), chicken ovalbumin upstream promoter transcription factor (COUPTF)- interacting protein 2 (CTIP 2), p300, PGC-1 a (PPAR g coactivator), and nuclear factor kB (NFkB) (Michan and Sinclair, 2007; Pillarisetti, 2008; Haigis and Guarente, 2006; Yamamoto et al., 2007).