2001) considered a broader variety of bound nonsteroidal ligands and found different possible binding modes within this C17[beta]-OH region, indicating the possibility of either an H-bond donor or acceptor interaction of the ligand with [Thr.
The present analysis considers the conformationally stretched distance between polar H-bond capable sites of known AR antagonists to be a measure of the potential of a molecule to express additional agonist properties.
These compounds did not, however, provide a good candidate feature for D-ring H-bond interaction according to the "near-10 [Angstrom] polar interactions rule" (the thiol was computed to be a 7.
Previous authors suggested that electron-withdrawal properties of the R3 phenyl substituent enhancing the H-bond acceptor capability at the R2 position are important for antagonism (Singh et al.
For the last of the three AR-LBD binding elements, multiple lines of evidence implicate a strong H-bond interaction in the vicinity of the D-ring (C17[beta]-OH) LBD binding region as being a necessary, but not sufficient, requirement for AR agonist activity.
6, the degree of H-bond of carboxyl groups in nanocomposites monotonically decreases with increasing content of AT in the matrix.
H-bond Effect on Dynamic Mechanical Properties of the Nanocomposites
Combining with the conclusion of FTIR analysis, the DMA results also showed that H-bond in the nanocomposites may act as a junction and constrained motion of the chains.
H-bond Effect on Crystallinity of the Nanocomposites
Cl is the maximum, the interaction between CPP and PANI is the strongest; the number of the intermolecular and inner-molecular H-bond in PANI-DBSA is the minimum, the intermolecular and innermolecular interaction of PANI-DBSA is the weakest, which indicates that the dispersion of PANI is the best homogeneous in the PP/PANI 4 composite.
This means that the interaction of the H-bond between C--C1 and N--H in the PP/PANI 4 composite is the strongest among the PP/CPP/PANI composites.
The intensity of the H-bond between C--Cl and N--H in PP/CPP/PANI composites and the intermolecular interaction between PANI-DBSA and CPP is closely correlated to the CPP content.