Effect of gestational diabetes on Purkinje and granule cells
distribution of the rat cerebellum in 21 and 28 days of postnatal life.
Multiple components of [Ca.sup.2+] channel facilitation in cerebellar granule cells
: expression of facilitation during development in culture.
Results: Treatment with 200 mg/kg, not 100 mg/kg, significantly increased number of BrdU-immunoreactive (+) and DCX+ cells (48.0 [+ or -] 3.1 and 72.0 [+ or -] 3.8 cells/section, respectively) in the subgranular zone (SGZ) of the dentate gyrus (DG) and BrdU+/NeuN+ cells (17.0 [+ or -] 1.5 cells/section) in the granule cell
layer as well as in the SGZ.
This can also be said of the granule cells
, as they project to the pyramidal cells, and account for a large amount of the neurons in the central nervous system,  indicating that the neural pathways in the hippocampus are intact.
Slides were blinded, and an unbiased stereological count of the estimated total number of DCXpositive neurons in the dentate gyrus granule cell
layer was performed.
In adults, mossy fibers normally project to proximal apical dendrites of pyramidal cells in the stratum lucidum (SL) of the CA3 (Figure 1(a)), whereas, during postnatal development, mossy fibers from the immature granule cells
extend to both the SL and stratum oriens (SO), forming both suprapyramidal bundles (SPB) and infrapyramidal bundles (IPB), respectively (Figure 1(b)).
LTP can be effectively induced in granule cells
in vivo by high-frequency stimulation of presynaptic perforant path fibers [13, 24-26].
One of the reasons the cerebellum has been so hard to study in detail is because of the extremely high density of the granule cells
present in it.
The number of somatic inhibitory synapses contacting dentate granule cells
has increased in epilepsy to about 125-135% of control values .
Furthermore, the presence of a persistent neurogenesis has recently been discovered in a specific region of the hippocampus, the dentate gyrus; it involves the main neuronal type present there, the granule cells
(for a review see ).
This type of radial migration is mostly performed by neurons that have executed tangential migration underneath the pial surface and includes granule cells
of the cerebellum (6) and neurons of the pontine nuclei (PN) in the hindbrain.