Ishibashi, "The role of neutral cholesterol ester hydrolysis in macrophage foam cells
," Journal of Atherosclerosis and Thrombosis, vol.
LDs are cytoplasmic organelles, present in high levels in foam cells
, that are comprised by a hydrophobic core of neutral lipids (triglycerides and cholesterol esters) surrounded by a phospholipid monolayer and a growing list of associated proteins [7-9].
Monocytes get attracted to and accumulate in the subendothelial space where they take up lipids to become foam cells
Histological specimens showed the aggregation of foam cells
; plasma cells, lymphocytes, and neutrophils were also noted.
studied the function of PMS on macrophage-derived foam cell
functions and found that PMS could reduce the high production of intercellular adhesion molecule- (ICAM-) 1 protein and the vascular endothelial growth factor (VEGF) protein levels in the medium induced by oxidized lipoprotein when analyzed by flow cytometry, suggesting that PMS is a powerful agent against atherosclerosis and that PMS action could possibly be through the inhibition of the production of ICAM-1 and VEGF in foam cells
At day 12, the mice were intraperitoneally injected with [sup.3]H-cholesterol-labeled macrophage-derived foam cells
, and the rate of macrophage RCT was determined .
Immunostaining of Kupffer cells in the liver and foam cells
in the liver and the hepatic lymph node for MAC 387 antibody proved that these cells are macrophages.
Moghe's group has designed nanoparticles that bind to molecules on the surface of macrophages, preventing them from gobbling fats and becoming foam cells
. The researchers made the nanoparticles specifically target a subtype of macrophage that's involved in atherosclerosis, not the macrophages that might respond to other injuries in the body.
In this article, we report the effects of darapladib on lipid profile, Ox-LDL level, number of foam cells
, and PVAT thickness in Sprague--Dawley rats that were given high-fat diet.
Inherent to the polymer's molecular design, PAPI 23 enables good airflow in and out of the foam cells
to help consumers achieve a better night's rest.
Posing another threat are foam cells
, which may live in the walls of the arteries, contributing to atherosclerosis.
(73,74) But these oxidized LDL laden macrophages can accumulate in the arterial wall, beneath the delicate endothelial layer, where they reside as so-called foam cells
. (75,76) And foam cells
, in turn, trigger inflammatory changes in the arterial wall, which eventually lead to the formation of an inflammatory plaque.