Comparison of FUT2 Gene Polymorphisms between UC Patients, CD Patients, and the Controls.
Haplotype Analysis of FUT2 Gene in IBD Patients and the Controls.
A total of 98 blood samples were genotyped by sequencing of the FUT2 gene.
A FUT2 gene common polymorphism determines resistance to rotavirus A of the P genotype.
Lowe, "Sequence and expression of a candidate for the human Secretor blood group [alpha](1,2)fucosyltransferase gene (FUT2
Diagnosis: The diagnosis of FUT1 or FUT2
deficiency can be confirmed by mutation analysis of the genes (191-193).
A region of the FUT2
gene was amplified, by using the following primers: forward 5'-CCCATCTTCAGAATCACCCTGCCGGTGCTG-3' and reverse 5'-TCGGCCGGCCCGTGGAAACATCCCC AGGTA-3', which anneal at positions 280-309 and 535-564, respectively, as described (18).
The biosynthesis of the sialylated [Le.sup.a] structure is complex and involves at least three genes, FUT3, FUT2
, and a sialyltransferase gene, that interact and compete with each other to produce the final products (Fig.
Moreover, a non-sense mutation in the fucosyltransferase gene 2 (FUT2
), which gives rise to the nonsecretor phenotype, has been found to provide almost complete protection from experimental and natural NoV infection (2,3).
The recent cloning of the secretor gene (FUT2
) and the identification of enzyme-inactivating mutations and gene fusion [25-30] may even make it possible to classify the secretors as homozygous wild-type and heterozygous at the FUT2
locus, once the geographical distribution of inactivating mutations has been documented.
We obtained 38 saliva samples from healthy persons with ABO, Secretor, and Lewis phenotypes, and we selected confirmed FUT2
(secretor) and FUT3 (Lewis) genotypes (4) to include ABO, secretor, and Lewis phenotypic diversity.
Several studies (6-11) have associated norovirus susceptibility with the presence of an [alpha]1,2-linked fucose on histo-blood group antigens (HBGAs), which is determined by the FUT2