Genetic sequencing analysis revealed a frameshift mutation (c.7539_7540insA) at exon 46 in FLNA gene, which was found in three patients (I 2, II 1, and II 3) of this family [Figure 1]d, but was not found in her healthy family members and the 110 unrelated normal controls [Figure 1]e.
The proband's elder sister (II 1) was thought to be a subclinical PNH patient due to positive family history, FLNA mutation, and multiple miscarriages.
As part of the plan PepsiCo expanded its Frito-Lay operating structure from the current two divisions -- Frito-Lay North America (FLNA
) and Frito-Lay International (FLI) -- by establishing two new companies -- Frito-Lay Europe/Middle East/Africa and Frito-Lay Latin America/Asia Pacific/Australia.
miRNA ID Target genes miR-26a TAB2, NLK, MEF2C, PAK1 miR-10b MAX, MEF2C, RAP1A let-7a-5p FLNA
, NGF, FAS, MEF2C, CASP3, RASGRP1 let-7f FLNA
, NGF, FAS, MEF2C, CASP3, RASGRP1 let-7i FLNA
, NGF, FAS, MEF2C, CASP3, RASGRP1 miR-27b EGFR, TAB2, NLK, NF1, FAS, STMN1, MEF2C, GRB2 miR-191 BDNF Table 4: Target genes regulated by differentially expressed miRNAs in TGF-[beta] signaling pathway miRNA ID Target genes miR-708 THBS1 miR-21-3p TGIF1, SP1 miR-409a PITX2, BMPR2 miR-335 DCN, FST, THBS1, RBL1, ACVR2A, LTBP1, BMPR2 miR-224 SMAD4, LTBP1, BMPR2 miR-214 CHRD, ACVR2A Table 5: The top 5 GO terms enriched by the pivotal miRNAs.