Increased incidence of FBXW7
and POLE proofreading domain mutations in young adult colorectal cancers.
The number of laboratories whose assay enabled the detection of a particular variant ranged from 85 (77%) for the FBXW7
p.R465H variant to 111 (100%) for the KRAS p.G13D variant (Table 1).
The primer sequences were provided as follows: FBXW7
forward, 5'-AAGGGCAA CAACGACG-3'; reverse, 5'-AGGGAGCAATGAAATGA AGT-3'.
They found that after its levels peaked during the day, two proteins, CDK1 and FBXW7
, interacted with REV-ERBα to help reduce its levels to a low point by the middle of the night.
The mutual exclusivity in serous tumors of CCNE1 amplification and somatic alterations affecting FBXW7
, which normally mediates the ubiquitin-mediated degradation of cyclin E, suggests that these genetic events are functionally redundant (16).
KRAS and TP53 were the most frequently mutated genes, but alterations were commonly found also in APC, SMAD4, FBXW7
, and BRAF genes.
Hu et al., "Wnt/[beta]-catenin signaling inhibits FBXW7
expression by upregulation of microRNA-770 in hepatocellular carcinoma," Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine, vol.
Nakayama, "Ablation of Fbxw7
eliminates leukemiainitiating cells by preventing quiescence," Cancer Cell, vol.
It was reported that the increased expression of hsa-miR-223 in ESCC might influence the expression of gene FBXW7
(18), which affected the prognosis of patients.
They discovered that three genes--CHD4, FBXW7
, and SPSO--are altered at a statistically high frequency in serous endometrial cancer.
(3) Lung SCCs are characterized by complex genomic alterations with recurrent mutations in several genes, including TP53, NFE2L2, KEAP1, BAI3, FBXW7
, GRM8, MUC16, RUNX1T1, STK11, ERBB4, DDR2, and FGFR1 amplification.
Among the 29 cases, Ion AmpliSeq Cancer Panel detected 9 actionable and investigational variants (9 of 29, 31.0%) occurring in the following genes: ERBB2 (3 of 29, 10.3%), STK11 (2 of 29, 6.8%), PTEN (2 of 29, 6.8%), FBXW7
(1 of 29, 3.4%), and BRAF G469A (1 of 29, 3.4%) (Table 2).