Defining the role of endothelins
in renal pathophysiology on the basis of selective and unselective endothelin
receptor antagonist studies.
Hjelmqvist, "Mixed endothelin
receptor antagonism with tezosentan improves intestinal microcirculation in endotoxemic shock," Journal of Surgical Research, vol.
Plasma immunoreactive endothelin
concentration correlates with severity of coronary artery disease in patients with stable angina pectoris and normal ventricular function.
Evidence is now strong for a role of the endothelin
system in diabetes.
as a natriuretic hormone: the case for a paracrine action mediated by nitric oxide.
Another recent study included 245 patients (ranging in age from 12 years to 78 years) vcho received bosentan, placebo, or one of two doses of a selective ETA endothelin
receptor antagonist, sitaxsentan.
Under normal conditions, the vascular endothelium secretes a variety of vasoactive substances including Endothelin
(ET) (Mukai et al.
Chronic blockade of nitric oxide-synthase and endothelin
receptors during pregnancy in the rat: Effect on pregnancy outcome.
The vasoconstrictor endothelin
-1 (ET-1) , a 21-amino acid peptide, is the most abundant member of the family of endothelins
including ET-1, ET-2, and ET-3.
Tokyo, Japan, Jan 25, 2006 - (JCN) - Kao, a leading Japanese cosmetics and toiletries manufacturer, announced on January 24 that its Biological Science Research Laboratories have elucidated the mechanism of skin flecks by quantitatively analyzing endothelin
and stem cell factor (SCF), a substance involved in melanocyte development.
Based on the properties of the compound and the results of our Phase 2 trial, we believe ambrisentan's efficacy and safety profile may position it as the best-in-class among endothelin
levels have been shown to occur with obesity, atherosclerosis, myocardial infarction, and diabetes.