cell

(redirected from Effector cell)
Also found in: Dictionary, Thesaurus, Medical, Legal, Encyclopedia, Wikipedia.

cell

an independent team of operatives who work together in a CELLULAR MANUFACTURING production environment.

References in periodicals archive ?

T cells are critical immune effector cells, and alteration in their function can have grave consequences on responses to primary infection and the acquisition of immunity.

Effects of developmental activation of the AhR on [CD4.sup.+] T-cell responses to influenza virus infection in adult mice

sup][8],[19] Consistent with previous studies, the findings of the current study demonstrated that, similar to the number and effector cell response of CD8[sup]+ Tem, the level of serum sTREM-1 expression was also significantly increased after IL-12 treatment and significantly decreased after adding rapamycin.

Role of Triggering Receptor Expressed on Myeloid Cell-1 Expression in Mammalian Target of Rapamycin Modulation of CD8[sup]+ T-cell Differentiation during the Immune Response to Invasive Pulmonary Aspergillosis

In the present study, we addressed the immunotoxic potential of the herbicide PRN on the effector cells of cell-mediated immunity, CTLs.

Propanil exposure induces delayed but sustained abrogation of cell-mediated immunity through direct interference with cytotoxic T-lymphocyte effectors

Like other proteins in the inhibitor of apoptosis protein family, survivin binds specifically to terminal effector cell death proteases, specifically caspase-3 and -7.

Detection of anti-survivin antibody in gastrointestinal cancer patients

The ADCC Reporter Bioassay uses an alternative readout at an earlier point in ADCC MOA pathway: the activation of gene transcription through the NFAT (nuclear factor of activated T-cells) pathway in the effector cell.

Promega Launches Novel ADCC Reporter Bioassay for Biologics

CAR technology activates T cell and Natural Killer cell functionality within one effector cell population, sourced from healthy donor or cord blood.

Formula Pharmaceuticals Initiates First Clinical Trial of Allogeneic CIK-CAR Cancer Immunotherapy

Results: Recent evidence has shown that miRNAs are involved in regulating fibrosis by targeting different substrates in the molecular processes that drive fibrosis, such as immune cell sensitization, effector cell activation, and extracellular matrix remodeling.

Regulatory Mechanisms of the Molecular Pathways in Fibrosis Induced by MicroRNAs

ADCC is a mechanism of cell-mediated immune defense in which an effector cell of the immune system, including Natural Killer (NK) cells, actively lyses a target cell.

Improving the functional characterization of biosimilars: new bioassay methods may help reduce the variability of analytical methods required to demonstrate comparability

Literature shared positive prediction of sting reactivity through allergy specific activity (the allergen-specific IgE to total IgE ratio; sIgE/T-IgE analysis) involving extensive effector cell activation along with allergen-specific IgE antibody's concentration, affinity (tightness of binding), clonality (epitope specificity) observations.

Use of sIgE/T-IgE in Predicting Systemic Reactions: Retrospective Analysis of 54 Honeybee Venom Allergy Cases in North China

Studies at two independent laboratories showed that rhIL-7 markedly improved host survival, blocked apoptosis of CD4 and CD8 T cells, restored IFN- production, and improved immune effector cell recruitment to the infected site.

Cytheris Announces Publication of Preclinical Study in Journal of Immunology Showing Interleukin-7 PromotesT Cell Viability, Trafficking, and Functionality While Improving Survival in Sepsis

This can be achieved either by engineering the antibody itself to optimize Fc effector functions such as ADCC and CDC, or adding payload functions to the antibody by incorporating a second targeting specificity to recruit immune effector cells or fusing it with toxins or cytokines.

Research and Markets: The Essential Antibody-Drug Conjugates (ADC) Competitor Analysis is Now Available

Xencor has applied its XmAb antibody engineering technology to improve the potency of XmAb2513 by engineering its Fc region to improve binding affinity to Fc(gamma) receptors, thereby enhancing engagement of immune effector cells and tumor-cell killing.

Xencor Presents Preliminary Phase I Data on XmAb[R]2513 Antibody for Lymphomas at 2009 American Society of Clinical Oncology Annual Meeting