Erythropoietin-producing hepatocellular receptor A4 (EphA4
) has been predicted to be a target of miR-10a.
Moreover, this miRNA was able to promote the EMT process in HCC through directly binding and repressing EPHA4
(EPH tyrosine kinase receptor A4) .
The Pax3 gene and the EphA4
gene act in concert with each other in causing spina bifida due to interstitial deletion at position 2q36 .
For example, in breast cancer, the physical interaction between TAMs and CSCs activates the EphA4
receptor on CSCs and the downstream Src and NF-[kappa]B pathways, which promote self-renewal .
Three studies [21, 22, 33] reported significant effects of G-Rg1 for decreasing the expression of erythropoietin-producing hepatocellular cell line such as EphA4
, EphB6, and EphB1 compared with the control group in the SNpc (P < 0.01 or P < 0.05).
Huang et al., "Blockade of EphA4
signaling ameliorates hippocampal synaptic dysfunctions in mouse models of Alzheimer's disease," Proceedings of the National Academy of Sciences of the United States of America, vol.
In our prediction list, five genes can be classified in such subfamily: EPHA3, EPHA4
, EPHA5, EPHA7, and EPHB2.
hsa_TGAATGT HECA, ACSL1, INO80, EPHA4
, PNRC2, et al.
The team, including faculty at the University of Massachusetts Medical School (UMMS), describes how the loss of activity of a receptor called EphA4
substantially extends the lifespan of people with the disease.
This communication was found while the neurobiologists were examining the signaling molecule ephrinA3 and its binding partner EphA4
One member of this family, EphA4
, is involved in the development of one of the major descending pathways in the spinal cord--the corticospinal tract (CST).