A proper amino terminus of diphtheria toxin
is important for cytotoxicity.
In this experiment, the knock-in vector was constructed using the porcine [beta]-casein genome locus, neo gene as the positive selection marker and diphtheria toxin
A as the negative selection marker.
Expression cloning of a diphtheria toxin
receptor: identity with a heparin-binding EGF-like growth factor precursor.
BioCancell's leading drug, BC-819, is a double stranded DNA plasmid construct that incorporates the gene for diphtheria toxin
(DTA) under the regulation of the promoter sequence for H19 gene.
Five of the 136 isolates had both A and B subunits of diphtheria toxin
(tox), detected by multiplex PCR, all of which appeared to be functional by sequence analysis (7).
Two known proteins, tetanus toxoid and CRM197, a nontoxic recombinant variant of diphtheria toxin
, are commonly used to develop these kinds of vaccines," explained Pantophlet.
They created a hybrid of diphtheria toxin
and interleukin-2 that binds exclusively to CD4 cells possessing the receptor and kills them.
Nonetheless, the geometric mean concentration of IgG against diphtheria toxin
in plasma of vaccinated adults who received the last dose of tetanus-diphtheria vaccine in their adolescence is not much over 0.
The researchers have already fused a variant of diphtheria toxin
into the Rad51 gene as a "toxic bomb" and tested it on a variety of cancer cell types, including breast cancer, fibrosarcoma, and cervical cancer cells.
Eight isolates demonstrated toxigenicity by the Elek immunoprecipitation test and by polymerase chain reaction testing (PCR), which can detect both A and B subunits of the diphtheria toxin
To induce this immune response against a woman's own hormone, scientists developing the vaccine anchored a synthetically produced portion of the hCG molecule to diphtheria toxin
, a combination capable of inducing strong antibody reaction against both substances.
pseudotuberculosis produce diphtheria toxin
(DT) and thus cause respiratory and cutaneous diphtheria.