Adenosine diphosphate ribosylation of aminoacyl transferase II and inhibition of protein synthesis by diphtheria toxin
Experimenting with a birth-control vaccine that uses the tetanus rather than diphtheria toxin
to stimulate antibodies is G.
Yet the protein does not harm other laboratory-grown cells that are very sensitive to diphtheria toxin
but lack MSH receptors.
Although diphtheria toxin
is not normally toxic to mouse cells, in their experiments the researchers will add a molecule to abnormal mouse DGCs that binds with the toxin.
Cambridge, UK) to remove the T cell epitopes from Diphtheria toxin
while retaining its cytotoxic potency.
Strain Diphtheria toxin
16S rRNA CD443 Nontoxigenic FJ409572 CD448 Nontoxigenic FJ409573 CD449 Nontoxigenic FJ409574 CD450 Nontoxigenic FJ409575 C.
ONTAK is a genetically engineered fusion toxin protein consisting of the amino acid sequences for the enzymatically-active portion of diphtheria toxin
fused to the sequence of human interleukin-2, resulting in a molecule that is cytotoxic for cells bearing the target IL-2 receptor.
He was one of the first to demonstrate the production of immunity by killed cultures of disease organisms and to show that a mixture of diphtheria toxin
and antitoxin confers immunity.
Anjin Group, with operations in Maryland and Massachusetts, is a biotechnology company developing a broad-based therapeutic platform for blood cancers, brain cancer and other diseases based on the fusion of a modified form of diphtheria toxin
to proteins capable of selectively targeting cancerous and diseased cells.
Insegia is comprised of a synthetic peptide derived from gastrin (G17), bound to an inactive form of the diphtheria toxin
(DT), which together elicit a powerful immune response against gastrin.
The leading drug BC-819, used in these clinical trials is a double stranded DNA plasmid construct that incorporates the gene for diphtheria toxin
(DTA) under the regulation of the promoter sequence for H19 gene.
Three of the five patients in the trial developed an improved immune response to HIV and also to diphtheria toxin