Clinical parameters of participants Parameter Values, n (%) Mean [+ or -] SD Type of DM Type 1 DM 27 (27) - Type 2 DM 73 (73) Duration of DM 1-15 71 (71) 13.2[+ or -]9.2 (years) >15 29 (29) DM-related diseases, No 31 (31) - Yes 69 (69) DM-related surgeries No 52 (52) - Yes 48 (48) Presence of DPN
No 59 (59) - Yes 41 (41) Presence of DN No 87 (87) - ([greater than or equal to] Yes 13 (13) stage 3) Presence of DR No 62 (62) - Yes 38 (38) DM: Diabetes mellitus, DPN
: Diabetic peripheral neuropathy, DN: Diabetic nephropahy, DR: Diabetic retinopathy, SD: Standard deviation Table 2.
These results suggest that this SOD2 SNP might potentially contribute to increased DPN
risk, presumably through oxidative stress-related disease mechanisms.
A cross-sectional study of 528 diabetic patients (191 newly diagnosed) used the Diabetic Neuropathy Symptom (DNS) score to establish a DPN
prevalence of 48.1%.
The features created with DPN
in the current work are in the order of microns (1-5 [micro]m in diameter) and submicrons (over 100 to over 400 nm in height), although nanometric sizes (50-100 nm) can be reached .
reported that dietary salsalate in combination with lower amounts of menhaden oil provided greater benefit in diabetes-induced vascular and neural impairment than menhaden oil alone, stressing the importance of combination therapy for the treatment of DPN
Among the downregulated genes, 221 unique genes were downregulated by E2 treatment, 174 unique genes were downregulated by PPT treatment, and 68 unique genes were downregulated by DPN
Duration of diabetes and duration of confirmed DPN
were significantly different between the two groups (p<0.05).
The average area and the density of myelin nerve fibers was decreased in the DPN
group as compared with the control group.
The severity of DPN
was assessed using the revised Neuropathy Disability Score (NDS)  and two subgroups were created: mild neuropathy (NDS < 6) or moderate/severe neuropathy (NDS [greater than or equal to] 6).
It has been postulated that individuals with DPN
exhibit significant deteriorations of gait performance compared to healthy controls or even persons with diabetes but no neuropathy symptoms .
Several studies have implicated oxidative stress, especially that resulting from mitochondrial insult, as being the prime event in the pathogenesis of DPN