Javitz et al., "Peripheral complement interactions with amyloid [beta] peptide in Alzheimer's disease: polymorphisms, structure, and function of complement receptor
1," Alzheimer's & Dementia, 2018.
Parasite-derived complement receptors
have also been proposed to control complement-mediated host damage.
1 and the molecular pathogenesis of malaria.
The complement receptor
gC1qR/p33, which recognizes the globular heads of C1q, is a multicompartmental and multifunctional protein and has been shown to play a role in reproduction in humans.
But on the surface of erythrocytes, C4d rises and complement receptor
1 declines with disease activity in SLE.
Ross GD, Cain AJ, Myaones BL, Newman SL, Lachmann PJ (1987) Specificity of membrane complement receptor
type three (CR3) for [beta]-glucans.
Human liver Kupffer cells express CR1, CR3, and CR4 complement receptor
Regulators of complement activation pathways are soluble (e.g., factor H) or membrane-associated, for example, CD35 (complement receptor
1 (CR1)), CD46 (membrane cofactor protein (MCP)), and CD55 (decay accelerating factor (DAF)).
Nicholson-Weller, "Complement receptor
1/CD35 is a receptor for mannan-binding lectin," The Journal of Experimental Medicine, vol.
Leppo et al., "Soluble human complement receptor
type 1: in vivo inhibitor of complement suppressing post-ischemic myocardial inflammation and necrosis," Science, vol.
A team of researchers now reports the identity of this protein as the complement receptor
1 (CR1), also known to help protect red cells from attack by the immune system.
Absence of an association between intercellular adhesion molecule 1, complement receptor
1 and interleukin 1 receptor antagonist gene polymorphisms and severe malaria in a West African population.