"We look forward to working with Merck KGaA, Darmstadt, Germany and Pfizer to determine an appropriate combination strategy
to help further improve outcomes for patients.
Although cost-effective, the SEDs-only strategy was dominated by a combination strategy
of both SEDs and training.
The combination strategy
can also be the combination of hands and facial expressions (e.g., wide opened eyes and raised eyebrows and hand covering mouth for intensification of surprise or shocked), or hand and head gesture (e.g., shaking head and waving hands for intensification of disinclination), or hands and shoulders (e.g., a shoulder shrug and open palms for intensification of 'I don't know').
Given previous results with standard therapy, enrollment in a clinical trial using a combination strategy
was considered a reasonable option.
However, no matter what kinds of combination strategy
are employed, the results have not varied a lot for one group of features and often remain in a certain range.
The Proposal is unclear as to critical elements of the combination strategy
, integration and potential consequences for its stakeholders;
"Our take-home is that for patients who are at extremely high risk of fracture, combination strategy
is a treatment strategy to be considered," said Dr.
Whether triple therapy or MTX + TNFi should be the preferred combination strategy
for patients with active RA despite treatment with MTX alone continues to be a matter of debate."
The partnership is claimed to strengthen combination strategy
in immuno-oncology, and underscore Merck KGaA, Darmstadt, Germany's science-driven approach to discovering and developing novel compounds through both internal capabilities and external collaborations.
It is well described that combination strategy
with dual checkpoint inhibition has remarkably improved the outcomes of patients.
"This anti-PD-1 resistance-associated gene expression pattern defined a signature which was also detected across other common cancers of the lung, colon, kidney and pancreas." Understanding who is likely to respond or not will help determine which patients can be treated with anti-PD-1 or require a combination strategy