Stream B: Immune Checkpoint Inhibitors & Combination Strategies
Hyleukin-7 amplifies and reinvigorates persistent T cell immunity in the treatment of patients with cancer and lymphopenia, thus providing unique opportunities for immuno-oncology combination strategies
According to the Chinese company, the combination strategies
have become a key area of clinical research and may unlock the potential of immuno-oncology therapies by combining two anti-cancer agents that could have a synergistic mechanism of action.
* Innovative combination strategies
to improve upon monotherapy activity and overcome resistance
Many IO combination strategies
focus on 'priming' the tumor, which is now becoming a prerequisite of turning a "cold" tumor into a "hot" tumor.
The two-day, three-stream congress will also focus on various combination strategies
, pre-clinical and translational immune-oncology developments, updates in cellular and viral therapies, vaccines development and personalized immunotherapy.
These data, discussed during a press conference at the 2018 Conference on Retroviruses and Opportunistic Infection in Boston, support further clinical investigation of combination strategies
involving bNAbs and a TLR7 agonist which may have the potential to achieve long-term viral suppression without the need for daily ART.
Understanding this novel mechanism of anti-CD47 therapy may make it possible to design new combination strategies
to improve current immune checkpoint blockade therapies by modulating the innate sensing of mtDNA.
To implement a two-dimensional DR navigation based on vehicle dynamic sensors, three different combination strategies
are designed to ensure that the vehicle dynamic sensors' information is not duplicated.
From the knowledge and experience of classical cytotoxic drugs, one of the solutions which have been put forth to overcome the challenges encountered in clinical practice is combination strategies