In this study, we have investigated the effects of repeated inhalation SS welding dust (WD) and its soluble form (SWD) on club (Clara) cells in the bronchiolar epithelium and Clara cell
protein (CC16) in rats and inquired whether the nuclear factor-kappa B (NF-[kappa]B) and or c-Jun/AP-1 related pathways were involved.
Ware, "Clara cell
protein (CC16), a marker of lung epithelial injury, is decreased in plasma and pulmonary edema fluid from patients with acute lung injury," Chest, vol.
CC16, an anti-inflammatory protein secreted by the Clara cells
of the distal respiratory epithelium, has been proposed as a biomarker of lung epithelial injury.
In this pilot study, the objective was to determine Clara cell
protein (CC16) concentration in BAL fluid from term and preterm infants with respiratory failure in whom bronchopulmonary dysplasia (BPD) was diagnosed subsequently.
Stripp, "Clara cell
secretory protein-expressing cells of the airway neuroepithelial body microenvironment include a label-retaining subset and are critical for epithelial renewal after progenitor cell depletion," The American Journal of Respiratory Cell and Molecular Biology, vol.
Surfactant protein D (SP-D) is a hydrophilic protein synthesized and secreted by alveolar epithelial type 2 and Clara cells
as an acute phase reactant in lung infections (6).
Ownby et al., "A critical review of the use of Clara cell
secretory protein (CC16) as a biomarker of acute or chronic pulmonary effects," Biomarkers, vol.
10-kDa protein (CC10 also known as CC16 SCGB1A1 uteroglobin) is a 10-kDa protein produced by non-ciliated Clara cells
and is one of the most abundant proteins in the fluids lining the airways.2 The CC10 gene is located on chromosome
Intratracheal Clara cell
secretory protein (CCSP) administration in preterm infants with or at risk of respiratory distress syndrome.
Polydatin up-regulates Clara cell
secretory protein to suppress phospholipase A2 of lung induced by LPS in vivo and in vitro.
The contributions of the 9 most abundant proteins were: albumin, 26%; surfactant proteins, 13% (including SP-A, 12%); various immunoglobulins, 14%; serotransferrin, 4%; Clara cell
protein (CC16), 4%; lysozyme C, 2%; proteases and inhibitors, 4% (including [[alpha].sub.1]-antitrypsin, 2%); annexins, 1%; and complement factors, 1%.
They also obtained serum and plasma samples for the following biomarkers: C-reactive protein, interleukin-8, interleukin-6, fibrinogen, tumor necrosis factor-alpha, surfactant protein D, and Clara cell
secretory protein 16 (CC-16).