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The chief cells also appear normal and occupy about a quadrant of the gastric mucosa.
The chief cells are distorted and shrunken and due to shrinkage, the pericellular spaces around these cells are very much increased.
Photomicrograph showing chief cells with pale eosinophilic cytoplasm and round to oval nuclei surrounded by sustentacular cells (hematoxylin-eosin, original magnification X20).
Present study revealed that oxyphil cells were less numerous than chief cells, placed either at periphery of gland adjacent to capsule or in the centre of gland.
In the new report, Mills, graduate student Greg Sibbel and Hans Clevers, MD, PhD, a geneticist at Utrecht Medical Centre, identified markers that show a small number of chief cells become stem cells even in the absence of serious injury.
Chief cells were intensely positive for neuro-endocrine markers such as chromogranin A (Figure 2B), synaptophysin.
In heavy drinkers, however the liver's chief cells -- called parenchymal cells -- can suffer such a severe damage that scar tissue forms, resulting in a condition known as cirrhosis.
Histologically, pernicious anemia is characterized by gastric mucosal atrophy, selective loss of parietal and chief cells from the gastric mucosa, and submucosal lymphocytic infiltrate.
The chief cells of the stomach wall secrete at least two enzymes that function in digestion.
Cytoplasmic and nuclear acidophilic inclusion bodies were detected in respiratory epithelial cells, gastric surface mucous and chief cells, intestinal crypt epithelial cells, and hepatic and pancreatic duct epithelial cells.