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Since inflammation plays a major role in the pathogenesis of cancers and CCR5 plays an important role in inflammation, the aim of this study was to investigate the association of human papillomavirus (HPV) infection and cancer progression to chemokine receptor 5 (CCR5) polymorphism.
While HIV has subverted the chemokine receptors CCR5 and CXCR4 for its own use as an entry co-receptor, their normal functions are to transduce signals in response to extracellular ligands.
The report provides a snapshot of the global therapeutic landscape for C-X-C Chemokine Receptor Type 2 (CDw128b or GRO/MGSA Receptor or High Affinity Interleukin-8 Receptor B or IL-8 Receptor Type 2 or CD182 or CXCR2)
CCR4 is a chemokine receptor found on DC, macrophages, NK cells, and basophiles, but it is predominantly known for its expression on T cells, especially of the Th2 phenotype.
The chemokine receptor CX3CRI controls homing and antiviral potencies of CD8 effector-memory T lymphocytes in HIVinfected patients.
CXCR7 is a chemokine receptor that was 'deorphanized' (a function was discovered for the protein encoded by a gene of previously unknown function) at ChemoCentryx through the company's proprietary EnabaLink Drug Discovery engine.
When investigators created mice lacking the chemokine receptor CXCR4, which is one that HIV exploits, the rodents died as embryos, their hearts and blood vessels riddled with defects.
The report provides comprehensive information on the C-C Chemokine Receptor Type 4 (C-C CKR-4 or K5-5 or CD194 or CCR4), targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type.
Plerixafor acts as an antagonist of the alpha chemokine receptor CXCR4, a procedure which is significant in hematopoietic stem cell homing to the bone marrow, doctors said.
In the study, the researchers demonstrate that the chemokine CCL5 helps to direct the recruitment of EPCs to sites of wounding by acting on the chemokine receptor CCR5.
Rockville, MD) has patented human G-protein chemokine receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques.
Malaria enhances expression of CC chemokine receptor 5 on placental macrophages.