C-X-C Chemokine Receptor
Type 2 (CDw128b or GRO/MGSA Receptor or High Affinity Interleukin 8 Receptor B or IL8 Receptor Type 2 or CD182 or CXCR2) pipeline Target constitutes close to 16 molecules.
The effective immune response to HCV infection requires efficient recruitment and activation of inflammatory cells (monocytes and T lymphocytes) to the infected liver in which chemokines and chemokine receptors
are involved and play important roles in the pathogenesis of chronic hepatitis C (8,9).
Aiello Talamanca et al., "Over expression of both CXC chemokine receptor
4 and vascular endothelial growth factor proteins predicts early distant relapse in stage II-III colorectal cancer patients," Clinical Cancer Research, vol.
This suggests that transformed cells secreting the chemokine adjuvant create an artificial, temporary gradient which recruits receptor-bearing immunocytes and leads to upregulation of the chemokine receptor
KEYWORDS: Atypical chemokine receptor
1, Hepatitis C virus, Liver damage, Liver fibrosis, Polymorphism, Serum liver related markers.
Genotyping of atypical chemokine receptor
1 was performed using a 5'-nuclease assay with TaqMan-minor groove binding probes.
(32) Most skin T cells express an E- and P-selectin--binding molecule, the cutaneous lymphocyte antigen (CLA), which is derived from the glycosylation of a lymphocyte sialomucin PSGL-1, and a chemokine receptor
CCR8, whose expression is induced by keratinocyte-derived factors.
CXCR4 serves as a chemokine receptor
for CXC chemokine ligand CXCL12 [also known as stromal cell-derived factor- (SDF-) 1 and pre-B-cell growth-stimulating factor (PBSF)], activates G proteins signaling transduction, and subsequently induces a rapid and transient rise in the level of intracellular calcium ions and chemotaxis [7, 8].
Caption: Figure 3: Signaling via chemokine receptor
Davenport, "Chemokine receptor
CCR5: from AIDS to atherosclerosis," British Journal of Pharmacology, vol.
Wiggins et al., "An agarose spot chemotaxis assay for chemokine receptor
antagonists," Journal of Pharmacological and Toxicological Methods, vol.
Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1alpha/CXC chemokine receptor